Guanosine

Guanosine

SCHEMBL3977221

Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1.O=C[C@H](O)[C@H](O)[C@H](O)CO

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.59
HINT1 P49773 4/20 0.55
NT5E P21589 1/20 0.55
GSK3A P49840 2/20 0.52
RPS6KA3 P51812 2/20 0.52
MAPK14 Q16539 2/20 0.52
PNP P00491 2/20 0.52
PAX8 Q06710 1/20 0.52
TGM2 P21980 1/20 0.51
ADORA3 P0DMS8 1/20 0.49
ADORA2A P29274 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guanosine SCHEMBL19810339 1.00 HPGD (0.59) HPGDHINT1NT5EGSK3ARPS6KA3
Guanosine SCHEMBL19810340 1.00 HPGD (0.59) HPGDHINT1NT5EGSK3ARPS6KA3
Guanosine SCHEMBL28166235 0.99 HPGD (0.58) HPGDHINT1NT5EGSK3ARPS6KA3
Guanosine SCHEMBL22498410 0.97 HPGD (0.58) HPGDHINT1NT5EGSK3ARPS6KA3
Guanosine SCHEMBL11066196 0.97 HPGD (0.58) HPGDHINT1NT5EGSK3ARPS6KA3
Guanosine SCHEMBL22498408 0.97 HPGD (0.58) HPGDHINT1NT5EGSK3ARPS6KA3
Guanosine SCHEMBL28068227 0.97 NT5E (0.58) HPGDHINT1NT5EGSK3ARPS6KA3
Guanosine SCHEMBL22498413 0.94 HPGD (0.54) HPGDHINT1NT5EGSK3ARPS6KA3
Guanosine SCHEMBL28048641 0.93 TGM2 (0.57) HPGDHINT1NT5EGSK3ARPS6KA3
Guanosine SCHEMBL27555600 0.91 HPGD (0.52) HPGDHINT1NT5EGSK3ARPS6KA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108103175-A A kind of method for being used to detect the mutation of EML4-ALK, ROS1 and RET fusion 序康医疗科技(苏州)有限公司 2018-06-01 CN claimed
CN-108103055-A A kind of method of unicellular RNA reverse transcriptions and library construction 上海亿康医学检验所有限公司 2018-06-01 CN claimed
CN-107893100-A A kind of unicellular mRNA reverse transcriptions and the method for amplification 序康医疗科技(苏州)有限公司 2018-04-10 CN claimed
CN-106661631-A Methods for identifying and enumerating nucleic acid sequences, expression, copies or DNA methylation changes using a combination of nucleases, ligases, polymerases and sequencing reactions 康奈尔大学 2017-05-10 CN claimed
CN-1578841-A Annealing control primer and use of the same VISION GENE CO LTD (KR) 2005-02-09 CN claimed
CN-118043466-A Substitution of nucleotide bases in self-amplified mRNA 葛兰素史克生物有限公司 2024-05-14 CN disclosed
CN-112641951-B Bioactive supermolecule chiral hydrogel and preparation method and application thereof 河南工业大学 2023-03-28 CN disclosed
CN-115074422-A Detection method of unknown fusion gene 北京泛生子基因科技有限公司 2022-09-20 CN disclosed
CN-111549099-B Third-generation sequencing-based single-cell transcriptome sequencing method 生物岛实验室 2021-07-30 CN disclosed
CN-112641951-A Bioactive supermolecule chiral hydrogel and preparation method and application thereof 河南工业大学 2021-04-13 CN disclosed
CN-111549099-A Third-generation sequencing-based single-cell transcriptome sequencing method 广州再生医学与健康广东省实验室 2020-08-18 CN disclosed
CN-110012671-A Normalization of NGS library concentrations 斯威夫特生物科学股份有限公司 2019-07-12 CN disclosed
US-6657052-B1 Labeling DNA or RNA at a specific site consisting of stable precursor, and only becomes reactive upon activation; alkylating only phosphodiester groups; lactonization reaction traps the trialkylphosphate in a stable form. UNIVERSITY OF ARKANSAS 2003-12-02 US disclosed
CN-1045539-C CDNA clones coding for polypepstides exhibiting human granulocyte macrophage and eosinophie cellular growth SCHERING BIOTECH CORP (US) 1999-10-13 CN disclosed
EP-0532878-B1 Process for producing acyclic nucleosides AJINOMOTO KK (JP) 1999-06-30 EP disclosed
US-5792868-A REACTING RIBONUCLEOSIDE IN THE PRESENCE OF AN ACID CATALYST WITH AN ACID ANHYDRIDE AND AN ESTER, SAPONIFYING AJINOMOTO CO., INC. (JP) 1998-08-11 US disclosed
US-5688948-A INTERMEDIATES FOR ACYCLOVIR AND GANCICLOVIR WITH CRYSTALLIZATION AJINOMOTO CO., INC. (JP) 1997-11-18 US disclosed
US-5336770-A Transglycosilation process for producing acyclic nucleosides AJINOMOTO CO., INC. (JP) 1994-08-09 US disclosed
EP-0532878-A2 Process for producing acyclic nucleosides Ajinomoto Co., Inc. (JP) 1993-03-24 EP disclosed
CN-1059562-A Reduce the method for carryover contamination in the amplification procedure AMGEN INC (US) 1992-03-18 CN disclosed