Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Guanosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | TGM2 | P21980 | 1/20 | 0.54 |
| ▸ | HINT1 | P49773 | 1/20 | 0.52 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.51 |
| ▸ | KRAS | P01116 | 5/20 | 0.51 |
| ▸ | GSK3A | P49840 | 2/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.49 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.49 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.49 |
| ▸ | PNP | P00491 | 1/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanosine SCHEMBL19810340 | 0.97 | HPGD (0.59) | NT5EHPGDTGM2HINT1GSK3A | |
| Guanosine SCHEMBL3977221 | 0.97 | HPGD (0.59) | NT5EHPGDTGM2HINT1GSK3A | |
| Guanosine SCHEMBL19810339 | 0.97 | HPGD (0.59) | NT5EHPGDTGM2HINT1GSK3A | |
| Guanosine SCHEMBL28166235 | 0.96 | HPGD (0.58) | NT5EHPGDTGM2HINT1GSK3A | |
| Guanosine SCHEMBL28048641 | 0.95 | TGM2 (0.57) | NT5EHPGDTGM2HINT1IMPDH2 | |
| Guanosine SCHEMBL11066196 | 0.94 | HPGD (0.58) | NT5EHPGDTGM2HINT1GSK3A | |
| Guanosine SCHEMBL22498410 | 0.94 | HPGD (0.58) | NT5EHPGDTGM2HINT1GSK3A | |
| Guanosine SCHEMBL22498408 | 0.94 | HPGD (0.58) | NT5EHPGDTGM2HINT1GSK3A | |
| E626 SCHEMBL27748771 | 0.91 | NT5E (0.66) | NT5ETGM2HINT1IMPDH2KRAS | |
| Guanosine SCHEMBL22498413 | 0.91 | HPGD (0.54) | NT5EHPGDTGM2HINT1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105524609-B | A kind of fluorescence probe GH and its preparation and application | 中国科学院大连化学物理研究所 | 2017-09-22 | — | — | CN | claimed |
| CN-105524609-A | Fluorescent probe GH and preparation method and application thereof | DALIAN INST CHEMICAL PHYSICS CAS | 2016-04-27 | — | — | CN | claimed |
| CN-105524609-B | A kind of fluorescence probe GH and its preparation and application | 中国科学院大连化学物理研究所 | 2017-09-22 | — | — | CN | disclosed |
| CN-105524609-B | A kind of fluorescence probe GH and its preparation and application | 中国科学院大连化学物理研究所 | 2017-09-22 | — | — | CN | disclosed |
| CN-105524609-A | Fluorescent probe GH and preparation method and application thereof | DALIAN INST CHEMICAL PHYSICS CAS | 2016-04-27 | — | — | CN | disclosed |