Guanosine

Guanosine

SCHEMBL28048641

Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1.O=CC(O)C(O)C(O)CO.O=P(O)(O)OP(=O)(O)OP(=O)(O)O

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TGM2 P21980 1/20 0.57
NT5E P21589 1/20 0.56
KRAS P01116 5/20 0.53
HPGD P15428 1/20 0.52
IMPDH2 P12268 6/20 0.52
FUT5 Q11128 1/20 0.52
HINT1 P49773 1/20 0.51
IMPDH1 P20839 2/20 0.50
P2RY2 P41231 2/20 0.49
P2RY4 P51582 1/20 0.49
P2RY6 Q15077 1/20 0.49
GSK3A P49840 2/20 0.48
RPS6KA3 P51812 2/20 0.48
MAPK14 Q16539 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guanosine SCHEMBL28068227 0.95 NT5E (0.58) TGM2NT5EKRASHPGDIMPDH2
Xylose SCHEMBL1422097 0.94 TGM2 (0.67) TGM2NT5EKRASIMPDH2FUT5
Guanosine SCHEMBL19810340 0.93 HPGD (0.59) TGM2NT5EHPGDHINT1GSK3A
Guanosine SCHEMBL19810339 0.93 HPGD (0.59) TGM2NT5EHPGDHINT1GSK3A
Guanosine SCHEMBL3977221 0.93 HPGD (0.59) TGM2NT5EHPGDHINT1GSK3A
Guanosine Triphosphate SCHEMBL27608840 0.93 TGM2 (0.66) TGM2NT5EKRASIMPDH2FUT5
Guanosine SCHEMBL28166235 0.92 HPGD (0.58) TGM2NT5EHPGDHINT1GSK3A
Guanosine SCHEMBL8429254 0.92 TGM2 (0.55) TGM2NT5EKRASHPGDIMPDH2
Guanosine SCHEMBL3264840 0.92 TGM2 (0.55) TGM2NT5EKRASHPGDIMPDH2
Guanosine SCHEMBL4816737 0.92 TGM2 (0.55) TGM2NT5EKRASHPGDIMPDH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105264093-B Pyrophosphorolysis is sequenced 伊鲁米纳剑桥有限公司 2018-04-10 CN disclosed
CN-105264093-A Pyrophosphorolytic sequencing ILLUMINA CAMBRIDGE LTD 2016-01-20 CN disclosed