Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 8/20 | 0.35 |
| ▸ | CTSG | P08311 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3988367 | 0.87 | RORC (0.40) | POLBKMT2AMEN1RORCMAOB | |
| SCHEMBL3989803 | 0.85 | ABCG2 (0.39) | KMT2AMEN1RAB9ARORCMAPT | |
| SCHEMBL4257168 | 0.83 | POLB (0.33) | CDK2POLBKMT2ALMNAMAPT | |
| SCHEMBL4259652 | 0.82 | NR4A2 (0.34) | CDK2KMT2AMEN1NPC1RAB9A | |
| SCHEMBL3972624 | 0.81 | POLB (0.55) | POLBKMT2AMEN1NPC1RAB9A | |
| SCHEMBL3990181 | 0.81 | RORC (0.39) | CDK2POLBKMT2AMEN1RORC | |
| SCHEMBL3992240 | 0.78 | POLB (0.38) | CDK2POLBKMT2ALMNAMAPT | |
| SCHEMBL3996013 | 0.78 | KDR (0.41) | CDK2POLBKMT2AMEN1LMNA | |
| SCHEMBL3995880 | 0.76 | NTRK1 (0.33) | — | |
| SCHEMBL3992947 | 0.76 | POLB (0.38) | CDK2POLBKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2065382-A1 | CGRP antagonists | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2009-06-03 | — | — | EP | disclosed |
| WO-2009050235-A1 | CGRP ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-23 | — | — | WO | disclosed |