SCHEMBL2890258

SCHEMBL2890258

O=C1c2ccccc2C(=O)N1c1cccc(N2C(=O)c3cccc(Cl)c3C2=O)c1

nearest known ligand 0.57

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HSPA1A P0DMV8 1/20 0.54
PABPC1 P11940 1/20 0.54
MEN1 O00255 2/20 0.51
KMT2A Q03164 2/20 0.51
NR1H3 Q13133 1/20 0.51
SCN2A Q99250 1/20 0.50
PGR P06401 1/20 0.48
ALDH1A1 P00352 2/20 0.48
KDM4E B2RXH2 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
TYMS P04818 1/20 0.47
CASP6 P55212 1/20 0.47
GRM5 P41594 1/20 0.47
DPP8 Q6V1X1 1/20 0.47
ADORA2A P29274 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1736347 0.97 HSPA1A (0.53) HSPA1APABPC1MEN1KMT2ANR1H3
SCHEMBL1500541 0.90 HSPA1A (0.67) HSPA1APABPC1MEN1KMT2ANR1H3
SCHEMBL3846075 0.90 ALDH1A1 (0.49) HSPA1APABPC1MEN1KMT2ANR1H3
SCHEMBL1735119 0.86 MEN1 (0.58) HSPA1APABPC1MEN1KMT2AALDH1A1
SCHEMBL19836885 0.86 KMT2A (0.56) HSPA1APABPC1MEN1KMT2APGR
SCHEMBL725608 0.84 NR1H3 (0.67) HSPA1APABPC1MEN1KMT2ANR1H3
SCHEMBL2892449 0.81 MEN1 (0.58) HSPA1APABPC1MEN1KMT2APGR
SCHEMBL13323538 0.81 KMT2A (0.54) HSPA1APABPC1MEN1KMT2ANR1H3
SCHEMBL20490838 0.81 MEN1 (0.53) HSPA1APABPC1MEN1KMT2AALDH1A1
SCHEMBL3979412 0.81 KMT2A (0.60) HSPA1APABPC1MEN1KMT2APGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2009521548-A 2009-06-04 JP claimed
EP-1966320-A2 HIGH GLASS TRANSITION TEMPERATURE THERMOPLASTIC ARTICLES General Electric Company (US) 2008-09-10 EP claimed
EP-1963432-A1 EXPANDED AND EXPANDABLE HIGH GLASS TRANSITION TEMPERATURE POLYMERS General Electric Company (US) 2008-09-03 EP claimed
EP-1963433-A2 ANNULAR OR TUBULAR SHAPED ARTICLES OF NOVEL POLYMER BLENDS General Electric Company (US) 2008-09-03 EP claimed
WO-2008091253-A1 HIGH HEAT ELECTRICAL CONNECTORS SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-07-31 WO claimed
WO-2008088336-A1 COATED ARTICLES OF MANUFACTURE MADE OF HIGH Tg POLYMER BLENDS SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-07-24 WO claimed
WO-2007078737-A1 EXPANDED AND EXPANDABLE HIGH GLASS TRANSITION TEMPERATURE POLYMERS GENERAL ELECTRIC COMPANY (US) 2007-07-12 WO claimed
WO-2007078713-A2 HIGH GLASS TRANSITION TEMPERATURE THERMOPLASTIC ARTICLES GENERAL ELECTRIC COMPANY (US) 2007-07-12 WO claimed
WO-2007075365-A2 ANNULAR OR TUBULAR SHAPED ARTICLES OF NOVEL POLYMER BLENDS GENERAL ELECTRIC COMPANY (US) 2007-07-05 WO claimed
US-20070149629-A1 Expanded and expandable high glass transition temperature polymers CITIBANK, N.A., AS COLLATERAL AGENT 2007-06-28 US claimed
US-20070142569-A1 Food service articles of manufacture comprising high temperature polymers CITIBANK, N.A., AS COLLATERAL AGENT 2007-06-21 US claimed
US-20070065615-A1 ANNULAR OR TUBULAR SHAPED ARTICLES OF NOVEL POLYMER BLENDS CITIBANK, N.A., AS COLLATERAL AGENT 2007-03-22 US claimed
US-20070066740-A1 Annular or tubular shaped articles of novel polymer blends CITIBANK, N.A., AS COLLATERAL AGENT 2007-03-22 US claimed
US-20070066739-A1 Coated articles of manufacture made of high Tg polymer blends GENERAL ELECTRIC COMPANY 2007-03-22 US claimed
US-20070066741-A1 High glass transition temperature thermoplastic articles CITIBANK, N.A., AS COLLATERAL AGENT 2007-03-22 US claimed
EP-1660556-A1 COPOLYETHERIMIDES GENERAL ELECTRIC COMPANY (US) 2006-05-31 EP claimed
WO-2005023901-A1 COPOLYETHERIMIDES GENERAL ELECTRIC COMPANY (US) 2005-03-17 WO claimed
US-6849706-B1 Copolyetherimides GENERAL ELECTRIC COMPANY (US) 2005-02-01 US claimed
EP-1660560-B1 PHASE TRANSFER CATALYZED METHOD FOR PREPARATION OF POLYETEHRIMIDES SABIC GLOBAL TECHNOLOGIES BV (NL) 2016-03-23 EP disclosed
US-6849706-B1 Copolyetherimides GENERAL ELECTRIC COMPANY (US) 2005-02-01 US disclosed