Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.40 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.40 |
| ▸ | CISD1 | Q9NZ45 | 8/20 | 0.37 |
| ▸ | PLK1 | P53350 | 3/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | KDM6B | O15054 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | NNMT | P40261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2434508 | 0.92 | CISD1 (0.34) | GUCY1A1GUCY1B1CISD1HSP90AA1HSP90AB1 | |
| SCHEMBL2426202 | 0.83 | CISD1 (0.52) | CISD1PLK1KDM4CKDM6B | |
| SCHEMBL3973544 | 0.81 | HSP90AA1 (0.39) | GUCY1A1GUCY1B1CISD1HSP90AA1HSP90AB1 | |
| SCHEMBL2431005 | 0.81 | CISD1 (0.49) | CISD1PLK1KDM4CKDM6BHSP90AA1 | |
| SCHEMBL3975516 | 0.80 | RXRB (0.34) | CISD1KDM4CHSP90AA1HSP90AB1NNMT | |
| SCHEMBL3980322 | 0.78 | HSP90AA1 (0.40) | CISD1KDM4CHSP90AA1HSP90AB1 | |
| SCHEMBL4258452 | 0.78 | MEN1 (0.34) | CISD1KDM4CKDM6BHSP90AA1HSP90AB1 | |
| SCHEMBL2422460 | 0.77 | JAK2 (0.40) | CISD1HSP90AA1HSP90AB1NNMT | |
| SCHEMBL2422093 | 0.76 | APEX1 (0.36) | CISD1 | |
| SCHEMBL2425956 | 0.75 | NNMT (0.37) | NNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074120-A1 | TROPANE COMPOUNDS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |