Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3972404 | 0.95 | SLC6A2 (0.44) | SLC6A2HDAC4HDAC7HDAC5CHRM2 | |
| SCHEMBL14489601 | 0.82 | LMNA (0.55) | SLC6A2HDAC4CHRM2CHRM1CHRM3 | |
| SCHEMBL13628924 | 0.82 | LMNA (0.55) | SLC6A2HDAC4CHRM2CHRM1CHRM3 | |
| SCHEMBL3972796 | 0.82 | SLC6A2 (0.54) | SLC6A2CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL3953392 | 0.82 | CHRM2 (0.41) | SLC6A2CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL3972425 | 0.82 | CHRM2 (0.41) | SLC6A2CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL3974416 | 0.82 | SLC6A2 (0.54) | SLC6A2CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL3973393 | 0.82 | CHRM2 (0.41) | SLC6A2CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL3956463 | 0.82 | SLC6A2 (0.54) | SLC6A2CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL27661848 | 0.82 | SLC6A2 (0.47) | SLC6A2LMNACES2CES1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7531543-B2 | Phenylpiperazine cycloalkanol derivatives and methods of their use | WYETH (US) | 2009-05-12 | — | — | US | disclosed |
| US-20050143394-A1 | Phenylpiperazine cycloalkanol derivatives and methods of their use | WYETH (US) | 2005-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143394-A1 | Phenylpiperazine cycloalkanol derivatives and methods of their use | HTR5A, PNMT, HTR3A | SLC6A2 49/4885HDAC4 3201/4885HDAC7 2635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.