Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 12/20 | 1.00 |
| ▸ | GRIK2 | Q13002 | 5/20 | 1.00 |
| ▸ | GRM1 | Q13255 | 1/20 | 1.00 |
| ▸ | GRM2 | Q14416 | 1/20 | 1.00 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.56 |
| ▸ | TET3 | O43151 | 1/20 | 0.56 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.56 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.47 |
| ▸ | GRIK3 | Q13003 | 4/20 | 0.47 |
| ▸ | GRIK5 | Q16478 | 4/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.46 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.44 |
| ▸ | GGT1 | P19440 | 2/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL497587 | 1.00 | GRIK1 (1.00) | GRIK1GRIK2GRM1GRM2TET2 | |
| SCHEMBL1476505 | 1.00 | GRIK1 (1.00) | GRIK1GRIK2GRM1GRM2TET2 | |
| Hydrochloric Acid SCHEMBL4186334 | 0.98 | GRIK1 (0.95) | GRIK1GRIK2GRM1GRM2TET2 | |
| Hydrochloric Acid SCHEMBL6235798 | 0.98 | GRIK1 (0.95) | GRIK1GRIK2GRM1GRM2TET2 | |
| Ammonia Solution, Strong SCHEMBL638403 | 0.98 | GRIK1 (0.95) | GRIK1GRIK2GRM1GRM2TET2 | |
| Lysine SCHEMBL7036667 | 0.83 | GRIK1 (0.69) | GRIK1GRIK2GRM1GRM2TET2 | |
| SCHEMBL1331822 | 0.83 | GRIK1 (0.71) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| SCHEMBL1331820 | 0.83 | GRIK1 (0.71) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| SCHEMBL5797481 | 0.81 | GRIK1 (0.68) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| Itaconate SCHEMBL27997562 | 0.81 | GRIK1 (0.67) | GRIK1GRIK2GRM1GRM2TET2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1062209-B1 | METABOLICALLY INERT ANTI-INFLAMMATORY AND ANTI-TUMOR ANTIFOLATES | NAIR MADHAVAN G (US) | 2009-05-13 | — | — | EP | disclosed |
| US-5912251-A | ENZYME INHIBITORS | CHELSEA THERAPEUTICS, INC. | 1999-06-15 | — | — | US | disclosed |