SCHEMBL497587

SCHEMBL497587

C=C(C[C@H](N)C(=O)O)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GRIK1 P39086 12/20 1.00
GRIK2 Q13002 5/20 1.00
GRM1 Q13255 1/20 1.00
GRM2 Q14416 1/20 1.00
TET2 Q6N021 3/20 0.56
TET3 O43151 1/20 0.56
TET1 Q8NFU7 1/20 0.56
GRIA4 P48058 4/20 0.47
GRIK3 Q13003 4/20 0.47
GRIK5 Q16478 4/20 0.47
SLC7A5 Q01650 1/20 0.46
GRIA2 P42262 3/20 0.45
GRIA1 P42261 2/20 0.45
PTGS1 P23219 1/20 0.44
SLC7A11 Q9UPY5 1/20 0.44
GGT1 P19440 2/20 0.43
SLC1A1 P43005 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1476505 1.00 GRIK1 (1.00) GRIK1GRIK2GRM1GRM2TET2
SCHEMBL3981383 1.00 GRIK1 (1.00) GRIK1GRIK2GRM1GRM2TET2
Hydrochloric Acid SCHEMBL4186334 0.98 GRIK1 (0.95) GRIK1GRIK2GRM1GRM2TET2
Hydrochloric Acid SCHEMBL6235798 0.98 GRIK1 (0.95) GRIK1GRIK2GRM1GRM2TET2
Ammonia Solution, Strong SCHEMBL638403 0.98 GRIK1 (0.95) GRIK1GRIK2GRM1GRM2TET2
Lysine SCHEMBL7036667 0.83 GRIK1 (0.69) GRIK1GRIK2GRM1GRM2TET2
SCHEMBL1331822 0.83 GRIK1 (0.71) GRIK1GRIK2GRM1GRM2GRIA4
SCHEMBL1331820 0.83 GRIK1 (0.71) GRIK1GRIK2GRM1GRM2GRIA4
SCHEMBL5797481 0.81 GRIK1 (0.68) GRIK1GRIK2GRM1GRM2GRIA4
Itaconate SCHEMBL27997562 0.81 GRIK1 (0.67) GRIK1GRIK2GRM1GRM2TET2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 811 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120000628-A Application of 4-methylene glutamic acid in pharmacy 桂林医学院附属医院 2025-05-16 CN claimed
WO-2025072741-A1 PRESERVATIVES FOR MOLECULAR SAMPLE ANALYSIS WITH SAMPLE COLLECTION DEVICES BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2025-04-03 WO claimed
US-20240197896-A1 SYNTHETIC PEPTIDE SHUTTLE AGENT BIOCONJUGATES FOR INTRACELLULAR CARGO DELIVERY FELDAN BIO INC. (CA) 2024-06-20 US claimed
CN-117750978-A Synthetic peptide shuttle bioconjugates for intracellular cargo delivery 费尔丹生物公司 2024-03-22 CN claimed
US-20230399661-A1 SHUTTLE AGENT PEPTIDES OF MINIMAL LENGTH AND VARIANTS THEREOF ADAPTED FOR TRANSDUCTION OF CAS9-RNP AND OTHER NUCLEOPROTEIN CARGOS FELDAN BIO INC. (CA) 2023-12-14 US claimed
US-20230383291-A1 PEPTIDE-BASED TRANSDUCTION OF NON-ANIONIC POLYNUCLEOTIDE ANALOGS FOR GENE EXPRESSION MODULATION FELDAN BIO INC. (CA) 2023-11-30 US claimed
CN-116615205-A Peptide-based transduction of non-anionic polynucleotide analogs for modulation of gene expression 费尔丹生物公司 2023-08-18 CN claimed
CN-116615227-A Minimum length shuttle peptide suitable for transduction of Cas9-RNP and other nucleoprotein loads and variants thereof 费尔丹生物公司 2023-08-18 CN claimed
US-20220204561-A1 PEPTIDE-BASED NON-PROTEINACEOUS CARGO DELIVERY FELDAN BIO INC. (CA) 2022-06-30 US claimed
CN-114008210-A Peptide-based non-protein cargo delivery 费尔丹生物公司 2022-02-01 CN claimed
WO-1999036409-A1 METABOLICALLY INERT ANTI-INFLAMMATORY AND ANTI-TUMOR ANTIFOLATES NAIR MADHAVAN G (US) 1999-07-22 WO claimed
US-5912251-A ENZYME INHIBITORS CHELSEA THERAPEUTICS, INC. 1999-06-15 US claimed
EP-0867430-A2 Glutamic acid derivatives and pharmaceutical compositions for the treatment of central nervous system disorders LILLY S.A. (ES) 1998-09-30 EP claimed
CN-1136764-A Flavouring compositions and its preparing method FIRMENICH & CIE (CH) 1996-11-27 CN claimed
US-5550128-A ANTITUMOR AGENTS NAIR, MADHAVAN G. 1996-08-27 US claimed
EP-0513068-B1 THREE NEW NON-POLYGLUTAMATABLE DEAZAAMINOPTERINS AND PROCESS FOR PREPARING THE SAME NAIR MADHAVAN G (US) 1995-09-13 EP claimed
US-5369142-A Curable mixtures with acrylic acid or methacrylic acid derivatives of amino acids THE OHIO STATE UNIVERSITY (US) 1994-11-29 US claimed
EP-0513068-A4 THREE NEW NON-POLYGLUTAMATABLE DEAZAAMINOPTERINS AND PROCESS FOR PREPARING THE SAME 1993-06-30 EP claimed
EP-0513068-A1 THREE NEW NON-POLYGLUTAMATABLE DEAZAAMINOPTERINS AND PROCESS FOR PREPARING THE SAME. NAIR MADHAVAN G (US) 1992-11-19 EP claimed
WO-1991010666-A1 THREE NEW NON-POLYGLUTAMATABLE DEAZAAMINOPTERINS AND PROCESS FOR PREPARING THE SAME NAIR MADHAVAN G (US) 1991-07-25 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240197896-A1 SYNTHETIC PEPTIDE SHUTTLE AGENT BIOCONJUGATES FOR INTRACELLULAR CARGO DELIVERY SCAMP2, SLC7A1, NUMA1 GRIK1 2487/4885GRIK2 2335/4885GRM1 2542/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.