Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 3/20 | 0.58 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.58 |
| ▸ | TERT | O14746 | 3/20 | 0.58 |
| ▸ | PPARD | Q03181 | 3/20 | 0.58 |
| ▸ | PPARA | Q07869 | 3/20 | 0.58 |
| ▸ | TOP1 | P11387 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | BLM | P54132 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | FABP4 | P15090 | 2/20 | 0.58 |
| ▸ | GMNN | O75496 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | APEX1 | P27695 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL3116844 | 0.94 | TSHR (0.70) | TSHRPTPN1TERTPPARGPPARD | |
| Maleic Acid SCHEMBL398163 | 0.94 | TSHR (0.70) | TSHRPTPN1TERTPPARGPPARD | |
| Maleic Acid SCHEMBL28894453 | 0.94 | TSHR (0.70) | TSHRPTPN1TERTPPARGPPARD | |
| Maleic Acid SCHEMBL6666189 | 0.94 | TSHR (0.70) | TSHRPTPN1TERTPPARGPPARD | |
| Maleic Acid SCHEMBL3116841 | 0.94 | TSHR (0.70) | TSHRPTPN1TERTPPARGPPARD | |
| Maleic Acid SCHEMBL28894368 | 0.94 | TSHR (0.70) | TSHRPTPN1TERTPPARGPPARD | |
| Acetic Acid SCHEMBL28975425 | 0.90 | TSHR (0.64) | TSHRPTPN1TERTPPARGPPARD | |
| Bicarbonate SCHEMBL28297401 | 0.88 | TSHR (0.73) | TSHRPTPN1TERTPPARGPPARD | |
| Acetic Acid SCHEMBL28362442 | 0.86 | F7 (0.60) | TSHRPTPN1TERTPPARGPPARD | |
| Urea SCHEMBL9615754 | 0.86 | FAAH (0.66) | TSHRPTPN1TERTPPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654068-A | Stain resists for polyamide substrates | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1997-08-05 | — | — | US | disclosed |
| US-5460887-A | Stain-resistant polyamide substrates | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1995-10-24 | — | — | US | disclosed |