Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | F10 | P00742 | 11/20 | 0.37 |
| ▸ | F2 | P00734 | 3/20 | 0.37 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL836499 | 0.90 | MET (0.40) | METTP53F10F2SLC29A1 | |
| SCHEMBL835601 | 0.74 | MET (0.51) | METNPSR1NPC1SMN1; SMN2LMNA | |
| SCHEMBL3984239 | 0.72 | HPGDS (0.43) | METTP53SMN1; SMN2MEN1KMT2A | |
| SCHEMBL837272 | 0.71 | MET (0.47) | METTP53HTTNPC1SMN1; SMN2 | |
| SCHEMBL838010 | 0.71 | KMT2A (0.46) | METHIF1AMEN1KMT2AMAPT | |
| SCHEMBL837728 | 0.70 | CHEK1 (0.46) | METNPC1SMN1; SMN2 | |
| SCHEMBL609306 | 0.70 | TP53 (0.59) | TP53F10F2SLC29A1HTT | |
| SCHEMBL29930365 | 0.70 | TP53 (0.59) | TP53F10F2SLC29A1HTT | |
| SCHEMBL836676 | 0.70 | MET (0.60) | MET | |
| SCHEMBL837789 | 0.70 | MET (0.47) | METNPC1SMN1; SMN2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057164-A1 | TRIAZOLOTRIAZINES AS KINASE INHIBITORS | Incyte Corporation (US) | 2009-05-13 | — | — | EP | claimed |
| WO-2008021781-A1 | TRIAZOLOTRIAZINES AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2008-02-21 | — | — | WO | claimed |