Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KLK7 | P49862 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL836247 | 0.90 | HSD11B1 (0.45) | HPGDSMAPK14EGLN1TP53POLB | |
| SCHEMBL838247 | 0.90 | HSD11B1 (0.45) | HPGDSMAPK14EGLN1TP53POLB | |
| SCHEMBL837528 | 0.87 | HSD11B1 (0.47) | HPGDSMAPK14TP53POLBFYN | |
| SCHEMBL835308 | 0.82 | HPGDS (0.44) | HPGDSEGLN1TP53POLBTTK | |
| SCHEMBL838827 | 0.78 | ALDH1A1 (0.50) | TP53HPGDSMN1; SMN2HSD11B1ALDH1A1 | |
| SCHEMBL837728 | 0.73 | CHEK1 (0.46) | EGLN1POLBSMN1; SMN2HSD11B1MET | |
| SCHEMBL836278 | 0.73 | BTK (0.40) | CCNE1CDK2PAK1 | |
| SCHEMBL3983206 | 0.72 | MET (0.40) | TP53SMN1; SMN2METMAPTMEN1 | |
| SCHEMBL11813023 | 0.72 | HPGDS (0.62) | HPGDSMAPK14HPGDSMN1; SMN2MEN1 | |
| SCHEMBL835601 | 0.70 | MET (0.51) | HPGDSMN1; SMN2HSD11B1METALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057164-A1 | TRIAZOLOTRIAZINES AS KINASE INHIBITORS | Incyte Corporation (US) | 2009-05-13 | — | — | EP | claimed |
| WO-2008021781-A1 | TRIAZOLOTRIAZINES AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2008-02-21 | — | — | WO | claimed |