Etidronic Acid

Etidronic Acid

SCHEMBL3983253

CC(O)(P(=O)([O-])[O-])P(=O)([O-])[O-].[Ca+2].[Ca+2]

nearest known ligand 0.47

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Known targets — ChEMBL curated mechanism

GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Etidronic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.47
FDPS P14324 4/20 0.33
SLC34A1 Q06495 1/20 0.33
GGPS1 O95749 1/20 0.32
ALDH1A1 P00352 2/20 0.32
THRB P10828 1/20 0.32
GRM4 Q14833 1/20 0.31
KDM4E B2RXH2 1/20 0.30
CYP2C19 P33261 1/20 0.30
KMT2A Q03164 1/20 0.30
PGK1 P00558 1/20 0.30
PGK2 P07205 1/20 0.30
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Etidronic Acid SCHEMBL8668700 0.93 LMNA (0.47) LMNAFDPSSLC34A1GGPS1ALDH1A1
Etidronic Acid SCHEMBL9851575 0.93 LMNA (0.47) LMNAFDPSSLC34A1GGPS1ALDH1A1
Etidronic Acid SCHEMBL8666317 0.93 LMNA (0.47) LMNAFDPSSLC34A1GGPS1ALDH1A1
Etidronic Acid SCHEMBL157065 0.93 LMNA (0.47) LMNAFDPSSLC34A1GGPS1ALDH1A1
Etidronic Acid SCHEMBL6136322 0.93 LMNA (0.47) LMNAFDPSSLC34A1GGPS1ALDH1A1
Etidronic Acid SCHEMBL1171139 0.93 LMNA (0.47) LMNAFDPSSLC34A1GGPS1ALDH1A1
Etidronic Acid SCHEMBL11584272 0.93 LMNA (0.47) LMNAFDPSSLC34A1GGPS1ALDH1A1
Etidronic Acid SCHEMBL7900083 0.93 LMNA (0.47) LMNAFDPSSLC34A1GGPS1ALDH1A1
Etidronic Acid SCHEMBL3897761 0.83 LMNA (0.60) LMNAFDPSSLC34A1GGPS1GRM4
Etidronic Acid SCHEMBL1515049 0.79 LMNA (0.63) LMNAFDPSSLC34A1GGPS1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4830779-A CONTAINING METAL POWDER, DIPHOSPHONATE, HYDROXYL COMPOUND LION CORPORATION (JP) 1989-05-16 US claimed
US-4747966-A DIPHOSPHONIC ACID, SEQUESTERING AGENT LION CORPORATION (JP) 1988-05-31 US claimed
US-7531490-B2 Detergent composition comprising calcium gluconate and a mixture of calcium ion sequestering agents KAO CORPORATION (JP) 2009-05-12 US disclosed
US-20060079437-A1 Detergent composition KAO CORPORATION (JP) 2006-04-13 US disclosed
US-4830779-A CONTAINING METAL POWDER, DIPHOSPHONATE, HYDROXYL COMPOUND LION CORPORATION (JP) 1989-05-16 US disclosed
US-4747966-A DIPHOSPHONIC ACID, SEQUESTERING AGENT LION CORPORATION (JP) 1988-05-31 US disclosed