Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 1/20 | 0.45 |
| ▸ | TACR2 | P21452 | 3/20 | 0.45 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3981129 | 0.96 | SERPINE1 (0.46) | SERPINE1TACR2EPHX2ALDH1A1POLB | |
| SCHEMBL3983675 | 0.89 | ALDH1A1 (0.46) | SERPINE1TACR2BDKRB1ALDH1A1KDM4E | |
| SCHEMBL3988840 | 0.85 | SERPINE1 (0.46) | SERPINE1ALDH1A1KDM4EPOLBCYP1A2 | |
| SCHEMBL3942225 | 0.85 | SERPINE1 (0.44) | SERPINE1TACR2BDKRB1EPHX2ALDH1A1 | |
| SCHEMBL4098217 | 0.85 | SERPINE1 (0.50) | SERPINE1ALDH1A1KDM4EPOLBCYP1A2 | |
| SCHEMBL3983400 | 0.84 | SERPINE1 (0.49) | SERPINE1ALDH1A1KDM4EPOLBCYP1A2 | |
| SCHEMBL3983700 | 0.84 | LMNA (0.48) | SERPINE1EPHX2ALDH1A1POLBJAK2 | |
| SCHEMBL3981944 | 0.84 | SERPINE1 (0.49) | SERPINE1BDKRB1ALDH1A1PKMPOLB | |
| SCHEMBL4618697 | 0.82 | ALDH1A1 (0.45) | SERPINE1TACR2BDKRB1ALDH1A1KDM4E | |
| SCHEMBL3982486 | 0.82 | SERPINE1 (0.45) | SERPINE1ALDH1A1POLBCRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888058-B1 | INHIBITORS OF SOLUBLE ADENYLATE CYCLASE | BAYER SCHERING PHARMA AG (DE) | 2009-05-20 | — | — | EP | claimed |