Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.40 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MPI | P34949 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3980812 | 0.80 | ALDH1A1 (0.44) | HTR2CHTR2BL3MBTL1KDM4EMAPT | |
| SCHEMBL3983651 | 0.78 | PTGDR2 (0.43) | MAPT | |
| SCHEMBL3984415 | 0.77 | HTR2C (0.43) | HTR2CHTR2BERCC1ERCC4L3MBTL1 | |
| SCHEMBL3980996 | 0.76 | PTGDR2 (0.39) | L3MBTL1KDM4EMAPTKMT2AMAPK1 | |
| SCHEMBL25328427 | 0.76 | KDM4E (0.47) | L3MBTL1KDM4EMPIMAPTKMT2A | |
| SCHEMBL10999896 | 0.69 | HTR2C (0.46) | HTR2CHTR2BERCC1ERCC4L3MBTL1 | |
| SCHEMBL8130133 | 0.65 | HTR2C (0.48) | HTR2CHTR2BL3MBTL1KDM4EMAPT | |
| SCHEMBL8130252 | 0.65 | HTR2C (0.48) | HTR2CHTR2B | |
| SCHEMBL3984193 | 0.63 | MAPT (0.50) | HTR2CHTR2BL3MBTL1KDM4EMAPT | |
| SCHEMBL15331281 | 0.63 | HTR2C (0.43) | HTR2CHTR2BERCC1ERCC4L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009060209-A1 | 6,6-FUSED BICYCLIC AROMATIC COMPOUNDS AND THEIR THERAPEUTI USE | ARGENTA DISCOVERY LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |