Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3980996 | 0.85 | PTGDR2 (0.39) | ALDH1A1KDM4EMAPTTSHRMAPK1 | |
| SCHEMBL3983651 | 0.82 | PTGDR2 (0.43) | MAPTTSHRTDP1 | |
| SCHEMBL3983803 | 0.80 | HTR2C (0.41) | KDM4EHPGDMAPTMAPK1L3MBTL1 | |
| SCHEMBL3984193 | 0.79 | MAPT (0.50) | ALDH1A1KDM4EHPGDMAPTTSHR | |
| SCHEMBL25328601 | 0.78 | ALDH1A1 (0.45) | ALDH1A1KDM4ETNKSTNKS2PARP2 | |
| SCHEMBL4300214 | 0.74 | MAPK1 (0.53) | ALDH1A1KDM4EHPGDMAPTTSHR | |
| SCHEMBL3989902 | 0.72 | MAPK1 (0.43) | ALDH1A1KDM4EHPGDMAPTTSHR | |
| SCHEMBL3985590 | 0.67 | CCNE2 (0.47) | ALDH1A1HPGDMAPTTSHRMAPK1 | |
| SCHEMBL3989921 | 0.66 | LMNA (0.41) | ALDH1A1KDM4EHPGDMAPTTSHR | |
| SCHEMBL3985579 | 0.65 | LMNA (0.44) | ALDH1A1KDM4EHPGDMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009060209-A1 | 6,6-FUSED BICYCLIC AROMATIC COMPOUNDS AND THEIR THERAPEUTI USE | ARGENTA DISCOVERY LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |