Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3987042 | 0.91 | USP2 (0.46) | OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL3987395 | 0.90 | OPRM1 (0.42) | OPRM1OPRD1CHRNA7OPRK1KCNH2 | |
| SCHEMBL3991588 | 0.89 | OPRM1 (0.44) | OPRM1OPRD1CHRNA7OPRK1KCNH2 | |
| SCHEMBL3991990 | 0.89 | ACHE (0.41) | OPRM1OPRD1 | |
| SCHEMBL13395003 | 0.85 | OPRM1 (0.55) | OPRM1OPRD1 | |
| SCHEMBL3173338 | 0.85 | OPRM1 (0.55) | OPRM1OPRD1 | |
| SCHEMBL13394993 | 0.85 | OPRM1 (0.55) | OPRM1OPRD1 | |
| SCHEMBL3987571 | 0.85 | P2RX4 (0.37) | OPRM1OPRD1 | |
| SCHEMBL3987430 | 0.85 | OPRK1 (0.42) | OPRM1OPRK1KCNH2 | |
| SCHEMBL3994605 | 0.84 | USP2 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833826-B1 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-05-27 | — | — | EP | claimed |