Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 4/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.40 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3989567 | 0.90 | LMNA (0.41) | TDP1TSHRMAPTPTGDR2PTGDR | |
| SCHEMBL3984323 | 0.84 | LMNA (0.43) | TSHRMAPTPDE10AKDM4EALDH1A1 | |
| SCHEMBL3989062 | 0.82 | PTGDR2 (0.49) | TDP1TSHRMAPTPPARDPTGDR2 | |
| SCHEMBL3981440 | 0.79 | MEN1 (0.38) | MAPTHPGDHSD17B10 | |
| SCHEMBL3988279 | 0.79 | TDP1 (0.47) | TDP1TSHRMAPTPPARDPTGDR2 | |
| SCHEMBL3771025 | 0.77 | TDP1 (0.48) | TDP1TSHRMAPTPPARDPTGDR2 | |
| SCHEMBL3782778 | 0.75 | PTGDR2 (0.46) | TDP1TSHRMAPTPPARDPTGDR2 | |
| SCHEMBL3985878 | 0.74 | PTGDR (0.51) | TDP1TSHRMAPTPTGDR2PTGDR | |
| SCHEMBL3983777 | 0.73 | TDP1 (0.55) | TDP1TSHRMAPTPPARDPTGDR2 | |
| SCHEMBL342560 | 0.73 | KDM4E (0.47) | TDP1TSHRMAPTPPARDPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009060209-A1 | 6,6-FUSED BICYCLIC AROMATIC COMPOUNDS AND THEIR THERAPEUTI USE | ARGENTA DISCOVERY LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |
| WO-2009060209-A1 | 6,6-FUSED BICYCLIC AROMATIC COMPOUNDS AND THEIR THERAPEUTI USE | ARGENTA DISCOVERY LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |