Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
| ▸ | HPGD | P15428 | 4/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | NPC1 | O15118 | 2/20 | 0.71 |
| ▸ | RAB9A | P51151 | 2/20 | 0.71 |
| ▸ | GAA | P10253 | 4/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 10/20 | 0.56 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | GABRP | O00591 | 1/20 | 0.51 |
| ▸ | GABRD | O14764 | 1/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3988373 | 0.95 | KDM4E (0.68) | KDM4EALDH1A1HPGDMAPTNPC1 | |
| SCHEMBL1121564 | 0.88 | KDM4E (0.59) | KDM4EALDH1A1HPGDMAPTNPC1 | |
| SCHEMBL7688090 | 0.87 | ALDH1A1 (0.74) | KDM4EALDH1A1HPGDMAPTNPC1 | |
| SCHEMBL3990672 | 0.86 | KDM4E (0.58) | KDM4EALDH1A1HPGDMAPTNPC1 | |
| SCHEMBL18531909 | 0.86 | GAA (0.63) | KDM4EALDH1A1HPGDMAPTNPC1 | |
| SCHEMBL6983821 | 0.85 | HCRTR1 (0.76) | KDM4EALDH1A1HPGDMAPTNPC1 | |
| SCHEMBL16732481 | 0.85 | KDM4E (0.71) | KDM4EALDH1A1HPGDMAPTNPC1 | |
| SCHEMBL3986203 | 0.85 | ALDH1A1 (0.55) | KDM4EALDH1A1HPGDMAPTNPC1 | |
| SCHEMBL3283431 | 0.84 | ALDH1A1 (0.69) | KDM4EALDH1A1HPGDMAPTNPC1 | |
| SCHEMBL4077176 | 0.84 | ALDH1A1 (0.69) | KDM4EALDH1A1HPGDMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125397-A1 | PREPARATION METHOD FOR AROMATIC RING DERIVATIVE FOR IMMUNE REGULATION | 上海济煜医药科技有限公司 | 2023-07-06 | — | — | WO | disclosed |
| US-20090233979-A1 | Indole Derivatives and Their Use as Thyroid Receptor Ligands | KARO BIO AB (SE) | 2009-09-17 | — | — | US | disclosed |
| EP-2035377-A1 | INDOLE DERIVATIVES AND THEIR USE AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007134864-A1 | INDOLE DERIVATIVES AND THEIR USE AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2007-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233979-A1 | Indole Derivatives and Their Use as Thyroid Receptor Ligands | TSHR, TRHR, THRA | KDM4E 1169/4885ALDH1A1 1439/4885HPGD 2564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.