Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3984196 | 0.85 | MAPT (0.41) | TDP1KDM4EHTTMAPT | |
| SCHEMBL3983777 | 0.80 | TDP1 (0.55) | TDP1TSHRMAPTPTGDR2 | |
| SCHEMBL3983780 | 0.77 | THRB (0.46) | TDP1TSHRMAP3K8THRATHRB | |
| SCHEMBL3984932 | 0.72 | TDP1 (0.46) | TDP1TSHRPPARGKDM4EMAPT | |
| SCHEMBL11377919 | 0.72 | LMNA (0.56) | PPARGMAP4K4 | |
| SCHEMBL11000247 | 0.69 | TDP1 (0.53) | TDP1TSHRMAP3K8MAPT | |
| SCHEMBL1888799 | 0.67 | KMT2A (0.46) | TDP1TSHRMAP3K8PPARGKDM4E | |
| SCHEMBL3979381 | 0.67 | LMNA (0.48) | TDP1TSHRKDM4EPKMHTT | |
| SCHEMBL23003709 | 0.66 | THRB (0.65) | TDP1TSHRTHRATHRBPPARG | |
| SCHEMBL3988279 | 0.66 | TDP1 (0.47) | TDP1TSHRPPARGKDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009060209-A1 | 6,6-FUSED BICYCLIC AROMATIC COMPOUNDS AND THEIR THERAPEUTI USE | ARGENTA DISCOVERY LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |
| WO-2009060209-A1 | 6,6-FUSED BICYCLIC AROMATIC COMPOUNDS AND THEIR THERAPEUTI USE | ARGENTA DISCOVERY LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |