Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3986256 | 0.85 | TDP1 (0.43) | MAPTHTTKDM4ETDP1 | |
| SCHEMBL3985274 | 0.81 | PTGDR2 (0.43) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL3986249 | 0.81 | HTT (0.40) | MAPTHTTKDM4EALDH1A1MEN1 | |
| SCHEMBL11460802 | 0.75 | NPSR1 (0.57) | MAPTHTTPOLBOPRK1P2RX3 | |
| SCHEMBL5494773 | 0.71 | KDM4E (0.45) | MAPTHTTKDM4EALDH1A1MEN1 | |
| SCHEMBL3979381 | 0.70 | LMNA (0.48) | MAPTHTTKDM4EALDH1A1MEN1 | |
| SCHEMBL3983780 | 0.68 | THRB (0.46) | HTTKDM4ETDP1ALOX5 | |
| SCHEMBL11608387 | 0.68 | KDM4E (0.42) | MAPTHTTKDM4EALDH1A1MEN1 | |
| SCHEMBL5207122 | 0.68 | GAA (0.66) | MAPTKDM4EALDH1A1POLBP2RX3 | |
| SCHEMBL11880114 | 0.67 | KDM4E (0.53) | MAPTKDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009060209-A1 | 6,6-FUSED BICYCLIC AROMATIC COMPOUNDS AND THEIR THERAPEUTI USE | ARGENTA DISCOVERY LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |