SCHEMBL3986924

SCHEMBL3986924

N=C(N)NCCCCCC(=O)NCCCCC(=O)O

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PRMT1 Q99873 1/20 0.55
EPHX2 P34913 3/20 0.54
ITGB3 P05106 5/20 0.52
ITGA2B P08514 5/20 0.52
ADRA1A P35348 1/20 0.52
LMNA P02545 2/20 0.47
TSHR P16473 2/20 0.47
KDM4E B2RXH2 1/20 0.47
MAPK1 P28482 1/20 0.46
MEN1 O00255 1/20 0.44
CYP1A2 P05177 1/20 0.44
KMT2A Q03164 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
PLA2G2A P14555 1/20 0.44
CASP2 P42575 1/20 0.43
NFKB1 P19838 1/20 0.43
PMP22 Q01453 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8770877 1.00 PRMT1 (0.55) PRMT1EPHX2ITGB3ITGA2BADRA1A
SCHEMBL26870168 1.00 PRMT1 (0.55) PRMT1EPHX2ITGB3ITGA2BADRA1A
SCHEMBL8770848 0.96 EPHX2 (0.50) PRMT1EPHX2ITGB3ITGA2BADRA1A
SCHEMBL20999515 0.95 ITGB3 (0.54) PRMT1EPHX2ITGB3ITGA2BADRA1A
SCHEMBL5535128 0.93 PRMT1 (0.63) PRMT1EPHX2ITGB3ITGA2BADRA1A
SCHEMBL5536799 0.93 PRMT1 (0.63) PRMT1EPHX2ITGB3ITGA2BADRA1A
SCHEMBL5533323 0.93 PRMT1 (0.63) PRMT1EPHX2ITGB3ITGA2BADRA1A
SCHEMBL5533492 0.93 PRMT1 (0.63) PRMT1EPHX2ITGB3ITGA2BADRA1A
SCHEMBL5531367 0.93 PRMT1 (0.63) PRMT1EPHX2ITGB3ITGA2BADRA1A
SCHEMBL5538332 0.93 PRMT1 (0.63) PRMT1EPHX2ITGB3ITGA2BADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10689415-B2 Conjugates of RGD peptides and (bacterio)chlorophyll photosensitizers YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 2020-06-23 US disclosed
EP-2061512-B1 CONJUGATES OF RGD PEPTIDES AND (BACTERIO)CHLOROPHYLL PHOTOSENSITIZERS AND THEIR USES YEDA RES & DEV (IL) 2019-10-02 EP disclosed
US-20180305405-A1 CONJUGATES OF RGD PEPTIDES AND PORPHYRIN OR (BACTERIO)CHLOROPHYLL PHOTOSYNTHESIZERS AND THEIR USES YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 2018-10-25 US disclosed
US-9957293-B2 Conjugates of RGD peptides and porphyrin or (bacterio)chlorophyll photosynthesizers and their uses YEDA RESEARCH AND DEVELOPMENT COMPANY LTD. (IL) 2018-05-01 US disclosed
US-20120294801-A1 CONJUGATES OF RGD PEPTIDES AND PORPHYRIN OR (BACTERIO)CHLOROPHYLL PHOTOSYNTHESIZERS AND THEIR USES YEDA RESEARCH AND DEVELOPMENT CO., LTD. (IL) 2012-11-22 US disclosed
EP-2061512-A1 CONJUGATES OF RGD PEPTIDES AND PORPHYRIN OR (BACTERIO)CHLOROPHYLL PHOTOSYNTHESIZERS AND THEIR USES YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 2009-05-27 EP disclosed
US-20080138278-A1 CONJUGATES OF RGD PEPTIDES AND PORPHYRIN OR (BACTERIO) CHLOROHYLL PHOTOSYNTHESIZERS AND THEIR USES YEDA RESEARCH & DEVELOPMENT CO., LTD. (IL) 2008-06-12 US disclosed
WO-2008023378-A9 CONJUGATES OF RGD PEPTIDES AND PORPHYRIN OR (BACTERIO)CHLOROPHYLL PHOTOSYNTHESIZERS AND THEIR USES YEDA RES & DEV (IL) 2008-04-10 WO disclosed
WO-2008023378-A1 CONJUGATES OF RGD PEPTIDES AND PORPHYRIN OR (BACTERIO)CHLOROPHYLL PHOTOSYNTHESIZERS AND THEIR USES YEDA RESEARCH AND DEVELOPMENT CO. LTD (IL) 2008-02-28 WO disclosed
EP-0617705-B1 NON-PEPTIDIC SURROGATES OF THE ARG-GLY-ASP SEQUENCE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM YEDA RES & DEV (IL) 1997-09-24 EP disclosed
WO-1996015789-A1 NON-PEPTIDIC SURROGATES OF ARG-GLY-ASP SEQUENCE AND USE YEDA RESEARCH AND DEVELOPMENT CO., LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE (IL) 1996-05-30 WO disclosed
US-5519005-A GUANIDINE TERMINATED PEPTIDES FOR TREATMENT OF THROMBOSIS, ANTITUMOR AGENTS, AUTOIMMUNE DISEASES AND IMMUNOLOGY YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 1996-05-21 US disclosed
US-5352667-A Inhibit cell adhesion YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 1994-10-04 US disclosed
WO-1993009795-A1 NON-PEPTIDIC SURROGATES OF THE ARG-GLY-ASP SEQUENCE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 1993-05-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10689415-B2 Conjugates of RGD peptides and (bacterio)chlorophyll photosensitizers MVD, AGER, FOLH1 PRMT1 2594/4885EPHX2 4024/4885ITGB3 1280/4885
US-20120294801-A1 CONJUGATES OF RGD PEPTIDES AND PORPHYRIN OR (BACTERIO)CHLOROPHYLL PHOTOSYNTHESIZERS AND THEIR USES MVD, DDOST, AGER PRMT1 2724/4885EPHX2 4322/4885ITGB3 2230/4885
US-20080138278-A1 CONJUGATES OF RGD PEPTIDES AND PORPHYRIN OR (BACTERIO) CHLOROHYLL PHOTOSYNTHESIZERS AND THEIR USES MVD, ALAD, PGLS PRMT1 2113/4885EPHX2 4120/4885ITGB3 2134/4885
US-20180305405-A1 CONJUGATES OF RGD PEPTIDES AND PORPHYRIN OR (BACTERIO)CHLOROPHYLL PHOTOSYNTHESIZERS AND THEIR USES MVD, DDOST, AGER PRMT1 2724/4885EPHX2 4322/4885ITGB3 2230/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.