Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ADH1B | P00325 | 1/20 | 0.39 |
| ▸ | ADH1C | P00326 | 1/20 | 0.39 |
| ▸ | ADH1A | P07327 | 1/20 | 0.39 |
| ▸ | ADH4 | P08319 | 1/20 | 0.39 |
| ▸ | ADH7 | P40394 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.37 |
| ▸ | FDPS | P14324 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2164250 | 1.00 | OPRM1 (0.44) | OPRM1CA1SPHK1LMNADNM1 | |
| SCHEMBL1426976 | 1.00 | OPRM1 (0.44) | OPRM1CA1SPHK1LMNADNM1 | |
| SCHEMBL5424869 | 1.00 | OPRM1 (0.44) | OPRM1CA1SPHK1LMNADNM1 | |
| SCHEMBL1109670 | 1.00 | OPRM1 (0.44) | OPRM1CA1SPHK1LMNADNM1 | |
| SCHEMBL14966766 | 0.97 | OPRM1 (0.46) | OPRM1CA1SPHK1LMNADNM1 | |
| SCHEMBL14966895 | 0.90 | DNM1 (0.38) | OPRM1CA1LMNADNM1TSHR | |
| SCHEMBL8587588 | 0.83 | GPR84 (0.49) | CA1SPHK1ACE2GPR84FDPS | |
| SCHEMBL29715649 | 0.81 | OPRM1 (0.46) | OPRM1CA1SPHK1LMNADNM1 | |
| SCHEMBL29364557 | 0.81 | OPRM1 (0.46) | OPRM1CA1SPHK1LMNADNM1 | |
| SCHEMBL11458298 | 0.80 | LMNA (0.44) | OPRM1CA1SPHK1LMNACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009056077-A2 | A NEW METHOD OF MANUFACTURING 2-(6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-LH-PYRROLIZINE-5-YL)ACETIC ACID (LICOFELONE) | ZENTIVA, A.S. (CZ) | 2009-05-07 | — | — | WO | disclosed |