Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 2/20 | 0.39 |
| ▸ | GABRD | O14764 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.39 |
| ▸ | GABRE | P78334 | 2/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.39 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.39 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.39 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.39 |
| ▸ | GRM8 | O00222 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28033030 | 0.80 | ADRA2A (0.39) | CYP2D6NFKB1BLMMAPTTET2 | |
| SCHEMBL28048592 | 0.79 | GABRP (0.39) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL15155706 | 0.79 | GABRP (0.39) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL23217529 | 0.77 | GAA (0.44) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL28228203 | 0.76 | GABRP (0.33) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL28246724 | 0.73 | DPP4 (0.37) | DPP4 | |
| SCHEMBL2318494 | 0.73 | DPP4 (0.31) | DPP4 | |
| SCHEMBL8515283 | 0.72 | ADRB2 (0.36) | BLMMAPTDPP4KDM4C | |
| SCHEMBL28021058 | 0.72 | ADRB2 (0.36) | BLMMAPTDPP4KDM4C | |
| SCHEMBL7453656 | 0.69 | FOLH1 (0.45) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203550-A1 | USE OF STEREOSELECTIVE TRANSAMINASE IN ASYMMETRIC SYNTHESIS OF CHIRAL AMINE | ABIOCHEM BIOTECHNOLOGY CO., LTD (CN) | 2023-06-29 | — | — | US | claimed |
| CN-104130149-B | A kind of recoverying and utilizing method of 3-(S)-amino butyric acid derivative | ZHEJIANG CHANGMING PHARMACEUTICAL CO., LTD. (CN) | 2016-01-27 | — | — | CN | claimed |
| CN-104130149-A | Recycling method of 3-(S)-aminobutyric acid derivative | ZHEJIANG CHANGMING PHARMACEUTICAL CO LTD | 2014-11-05 | — | — | CN | claimed |
| CN-109896980-A | A kind of biological synthesis method of sitagliptin intermediate | 浙江九洲药业股份有限公司 | 2019-06-18 | — | — | CN | disclosed |
| CN-109824546-A | BOC- (R) -3- amino -4- (2,4,5- trifluorophenyl) butyric acid is condensed impurity and preparation method thereof | 浙江永太科技股份有限公司 | 2019-05-31 | — | — | CN | disclosed |
| CN-109608348-A | A kind of synthetic method of (R) -3- t-butoxycarbonyl amino -4- (2,4,5- trifluorophenyl) butyric acid | 凯瑞斯德生化(苏州)有限公司 | 2019-04-12 | — | — | CN | disclosed |
| CN-105294479-B | A kind of 3R amino replaces the preparation method of butanamide derivatives | 新发药业有限公司 | 2017-09-22 | — | — | CN | disclosed |
| CN-106966940-A | A kind of preparation method of Sitagliptin phosphate intermediate N arylmethyls 2S cyano methyl acridines | 新发药业有限公司 | 2017-07-21 | — | — | CN | disclosed |
| CN-105061434-B | Preparation method of sitagliptin phosphate | 新发药业有限公司 | 2017-07-21 | — | — | CN | disclosed |
| CN-106801043-A | One kind restructuring transaminase and its preparation method and application | 江苏阿尔法药业有限公司 | 2017-06-06 | — | — | CN | disclosed |
| CN-103483340-B | A kind of synthetic method of sitagliptin | 无锡佰翱得生物科学有限公司 | 2016-09-07 | — | — | CN | disclosed |
| CN-104130149-B | A kind of recoverying and utilizing method of 3-(S)-amino butyric acid derivative | ZHEJIANG CHANGMING PHARMACEUTICAL CO., LTD. (CN) | 2016-01-27 | — | — | CN | disclosed |
| CN-104130149-A | Recycling method of 3-(S)-aminobutyric acid derivative | ZHEJIANG CHANGMING PHARMACEUTICAL CO LTD | 2014-11-05 | — | — | CN | disclosed |
| WO-2013114173-A1 | A NOVEL PROCESS FOR THE PREPARATION OF SITAGLIPTIN | SMILAX LABORATORIES LIMITED (IN) | 2013-08-08 | — | — | WO | disclosed |
| CN-102159578-A | Salts of tetrahydroimidazo [1,5-a] pyrazine derivatives, preparation methods and pharmaceutical use thereof | JIANGSU HENGRUI MEDICINE CO | 2011-08-17 | — | — | CN | disclosed |
| US-20090192326-A1 | Preparation of sitagliptin intermediate | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2009-07-30 | — | — | US | disclosed |
| WO-2009064476-A1 | PREPARATION OF SITAGLIPTIN INTERMEDIATE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2009-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192326-A1 | Preparation of sitagliptin intermediate | DPP4, DPP7, DPP3 | GABRP 1223/4885GABRD 1396/4885GABRA1 1200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.