Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3168323 | 0.81 | OPRM1 (0.39) | OPRM1OPRD1OPRK1KCNH2CHRM1 | |
| SCHEMBL3183048 | 0.76 | OPRM1 (0.38) | OPRM1OPRD1OPRK1KCNH2CHRM1 | |
| SCHEMBL3176047 | 0.74 | DRD2 (0.38) | OPRM1OPRK1KCNH2CHRM1CYP2D6 | |
| SCHEMBL13394866 | 0.74 | DRD2 (0.38) | OPRM1OPRK1KCNH2CHRM1CYP2D6 | |
| SCHEMBL3167461 | 0.73 | OPRM1 (0.35) | OPRM1OPRD1OPRK1KCNH2CHRM1 | |
| SCHEMBL3173021 | 0.71 | OPRM1 (0.48) | OPRM1OPRD1CHRM1HDAC6HDAC3 | |
| SCHEMBL3987443 | 0.70 | OPRM1 (0.40) | OPRM1OPRD1OPRK1KCNH2CHRM1 | |
| SCHEMBL5221409 | 0.67 | OPRM1 (0.37) | OPRM1OPRK1KCNH2CHRM1 | |
| SCHEMBL13394765 | 0.66 | OPRM1 (0.39) | OPRM1OPRD1OPRK1KCNH2CHRM1 | |
| SCHEMBL3168029 | 0.66 | OPRM1 (0.39) | OPRM1OPRD1OPRK1KCNH2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833826-B1 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-05-27 | — | — | EP | disclosed |