Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 5/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 10/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR1E | P28566 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3982599 | 0.84 | SLC6A3 (0.53) | SLC6A2SLC6A3SLC6A4CHRM5CHRM2 | |
| SCHEMBL4756289 | 0.83 | SLC6A3 (0.53) | SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL3981548 | 0.82 | PTGDR2 (0.50) | PTGDR2TMEM97SIGMAR1 | |
| SCHEMBL17474538 | 0.78 | CHRM5 (0.60) | SLC6A2SLC6A3SLC6A4CHRM5CHRM2 | |
| SCHEMBL4049327 | 0.77 | SLC6A3 (0.60) | SLC6A2SLC6A3SLC6A4CHRM5CHRM2 | |
| SCHEMBL4399188 | 0.77 | TMEM97 (0.49) | SLC6A2SLC6A3CHRM5CHRM2CHRM4 | |
| SCHEMBL31315800 | 0.76 | TMEM97 (0.51) | SLC6A2SLC6A3CHRM5CHRM2CHRM4 | |
| SCHEMBL17485170 | 0.75 | SLC6A3 (0.55) | SLC6A2SLC6A3SLC6A4CHRM5CHRM2 | |
| SCHEMBL3197591 | 0.75 | SLC6A3 (0.55) | SLC6A2SLC6A3SLC6A4CHRM5CHRM2 | |
| SCHEMBL29995210 | 0.74 | MEN1 (0.54) | PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061461-B1 | 3-AZABICYCLO[4.1.0]HEPTANE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | GLAXO GROUP LTD (GB) | 2009-12-23 | — | — | EP | disclosed |
| EP-2061461-B1 | 3-AZABICYCLO[4.1.0]HEPTANE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | GLAXO GROUP LTD (GB) | 2009-12-23 | — | — | EP | disclosed |
| US-20090281135-A1 | 3-AZABICYCLO [4. 1. 0] HEPTANE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | GLAXO GROUP LIMITED (GB) | 2009-11-12 | — | — | US | disclosed |
| US-20090281135-A1 | 3-AZABICYCLO [4. 1. 0] HEPTANE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | GLAXO GROUP LIMITED (GB) | 2009-11-12 | — | — | US | disclosed |
| US-20090281135-A1 | 3-AZABICYCLO [4. 1. 0] HEPTANE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | GLAXO GROUP LIMITED (GB) | 2009-11-12 | — | — | US | disclosed |
| EP-2061461-A2 | 3-AZABICYCLO[4.1.0]HEPTANE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | Glaxo Group Limited (GB) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008031771-A2 | 3-AZABICYCLO [4. 1. 0] HEPTANE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | GLAXO GROUP LIMITED (GB) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008031771-A2 | 3-AZABICYCLO [4. 1. 0] HEPTANE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | GLAXO GROUP LIMITED (GB) | 2008-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281135-A1 | 3-AZABICYCLO [4. 1. 0] HEPTANE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | HTR5A, ADRA2C, SLC6A3 | SLC6A2 8/4885SLC6A3 3/4885SLC6A4 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.