Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3982702 | 0.80 | CASP3 (0.41) | ALDH1A1HTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3986581 | 0.79 | HDAC6 (0.44) | HDAC6ALDH1A1HTTSMN1; SMN2NPC1 | |
| SCHEMBL3984081 | 0.78 | ALDH1A1 (0.48) | ALDH1A1HTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3982684 | 0.78 | ALDH1A1 (0.39) | ADORA2AADORA1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL3981762 | 0.77 | NPC1 (0.42) | ALDH1A1HTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3985676 | 0.74 | AR (0.33) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL3982707 | 0.73 | RAB9A (0.42) | ALDH1A1HTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3984913 | 0.72 | CASP3 (0.39) | ALDH1A1HTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3986963 | 0.71 | MEN1 (0.40) | ALDH1A1HTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL382157 | 0.70 | POLB (0.50) | HDAC6ALDH1A1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598237-B2 | 7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators | WYETH (US) | 2009-10-06 | — | — | US | disclosed |
| US-20080139530-A1 | 7-Aryl 1,5-Dihydro-4,1-Benzoxazepin-2(3H)-One Derivatives And Their Use As Progesterone Receptor Modulators | WYETH (US) | 2008-06-12 | — | — | US | disclosed |
| US-20080113964-A1 | 7-Aryl 1,5-Dihydro-4,1-Benzoxazepin-2(3H)-One Derivatives and Their Use As Progesterone Receptor Modulators | WYETH (US) | 2008-05-15 | — | — | US | disclosed |
| US-7323455-B2 | 7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators | WYETH (US) | 2008-01-29 | — | — | US | disclosed |
| WO-2005095366-A1 | 7-ARYL 1,5-DIHYDRO-4,1-BENZOXAZEPIN-2(3H)-ONE DERIVATIVES AND THEIR USE AS PROGESTERONE RECEPTOR MODULATORS | WYETH (US) | 2005-10-13 | — | — | WO | disclosed |
| US-20050215539-A1 | 7-aryl 1,5-dihydro-4, 1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators | WYETH (US) | 2005-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113964-A1 | 7-Aryl 1,5-Dihydro-4,1-Benzoxazepin-2(3H)-One Derivatives and Their Use As Progesterone Receptor Modulators | PGR, GPER1, PGRMC2 | ADORA2A 908/4885ADORA1 851/4885HDAC6 1939/4885 |
| US-20080139530-A1 | 7-Aryl 1,5-Dihydro-4,1-Benzoxazepin-2(3H)-One Derivatives And Their Use As Progesterone Receptor Modulators | PGR, GPER1, PGRMC2 | ADORA2A 908/4885ADORA1 851/4885HDAC6 1939/4885 |
| US-20050215539-A1 | 7-aryl 1,5-dihydro-4, 1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators | PGR, GPER1, PGRMC2 | ADORA2A 908/4885ADORA1 851/4885HDAC6 1939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.