Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3989054 | 0.84 | CRBN (0.38) | PARP1CRBNCCNCCDK8CDK19 | |
| SCHEMBL14414389 | 0.80 | ALDH1A1 (0.44) | HTTKDM4EALDH1A1PARP1CRBN | |
| SCHEMBL18347987 | 0.79 | CHRNB2 (0.38) | PARP1CRBNCCNCCDK8CDK19 | |
| SCHEMBL20215842 | 0.79 | OPRM1 (0.39) | ALDH1A1PARP1CRBNCCNCCDK8 | |
| SCHEMBL29889238 | 0.74 | CRBN (0.59) | GAAHTTKDM4EALDH1A1CRBN | |
| SCHEMBL21634313 | 0.72 | ALDH1A1 (0.48) | GAAALDH1A1CRBNDDB1 | |
| SCHEMBL31622202 | 0.71 | GAA (0.40) | GAAHTTKDM4EALDH1A1CRBN | |
| SCHEMBL5562592 | 0.70 | HIF1A (0.56) | ALDH1A1 | |
| SCHEMBL9963246 | 0.70 | CYP2D6 (0.36) | GAAKDM4EALDH1A1CCNCCDK8 | |
| SCHEMBL29890275 | 0.70 | OTUD7B (0.46) | GAAHTTKDM4EALDH1A1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035420-A2 | KV1.5 POTASSIUM CHANNEL INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-03-18 | — | — | EP | claimed |
| WO-2007149873-A2 | KV1.5 POTASSIUM CHANNEL INHIBITORS | WYETH (US) | 2007-12-27 | — | — | WO | claimed |