SCHEMBL3989019

SCHEMBL3989019

[CH]C1c2cc(Cl)ccc2-c2ccc(Cl)cc21

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S100A4 P26447 2/20 0.41
PPOX P50336 1/20 0.37
AHR P35869 1/20 0.37
HTR2B P41595 2/20 0.37
CHRNB2 P17787 1/20 0.36
CHRNA4 P43681 1/20 0.36
TP53 P04637 1/20 0.36
CYP1A2 P05177 1/20 0.35
GPR3 P46089 1/20 0.34
CES1 P23141 2/20 0.33
LMNA P02545 1/20 0.33
CYP2A6 P11509 1/20 0.33
PDK2 Q15119 1/20 0.33
TGM2 P21980 1/20 0.33
ALDH1A1 P00352 1/20 0.33
CYP3A4 P08684 1/20 0.33
ALOX15 P16050 1/20 0.33
TSHR P16473 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
TDP1 Q9NUW8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8993316 0.75 S100A4 (0.41) S100A4PPOXAHRHTR2BCHRNB2
SCHEMBL30633032 0.75 S100A4 (0.41) S100A4PPOXAHRHTR2BCHRNB2
SCHEMBL29721914 0.70 S100A4 (0.37) S100A4PPOXAHRHTR2BCHRNB2
SCHEMBL30633075 0.70 HTR2B (0.40) S100A4PPOXAHRHTR2BCHRNB2
SCHEMBL19514779 0.70 CYP1A2 (0.42) S100A4PPOXAHRHTR2BCHRNB2
SCHEMBL113826 0.70 S100A4 (0.37) S100A4PPOXAHRHTR2BCHRNB2
SCHEMBL18748423 0.70 S100A4 (0.41) S100A4PPOXAHRHTR2BCHRNB2
SCHEMBL8993321 0.70 HTR2B (0.40) S100A4PPOXAHRHTR2BCHRNB2
SCHEMBL28907669 0.70 CYP1A2 (0.46) S100A4AHRHTR2BTP53CYP1A2
SCHEMBL9542340 0.67 CYP1A2 (0.44) S100A4PPOXAHRHTR2BCHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009067541-A2 INTEGRASE INHIBITORS GILEAD SCIENCES, INC. (US) 2009-05-28 WO disclosed
EP-1641762-A2 CCK-1 RECEPTOR MODULATORS JANSSEN PHARMACEUTICA N.V. (BE) 2006-04-05 EP disclosed
EP-1567494-A1 METHODS FOR PREPARING PHENYLALKYNE DERIVATIVES Ortho-McNeil Pharmaceutical, Inc. (US) 2005-08-31 EP disclosed
WO-2005005393-A2 CCK-1 RECEPTOR MODULATORS JANSSEN PHARMACEUTICA N.V. (BE) 2005-01-20 WO disclosed
WO-2004050623-A1 METHODS FOR PREPARING PHENYLALKYNE DERIVATIVES ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2004-06-17 WO disclosed