Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9577115 | 0.85 | MAPT (0.74) | ALDH1A1L3MBTL1MAPTMCOLN3LMNA | |
| SCHEMBL28820135 | 0.84 | ALDH1A1 (0.97) | ALDH1A1L3MBTL1MAPTMCOLN3LMNA | |
| SCHEMBL10453953 | 0.83 | ALDH1A1 (0.77) | ALDH1A1L3MBTL1MAPTMCOLN3LMNA | |
| SCHEMBL15916526 | 0.78 | MAPT (0.97) | ALDH1A1L3MBTL1MAPTMCOLN3LMNA | |
| SCHEMBL9577236 | 0.77 | MAPT (0.62) | ALDH1A1L3MBTL1MAPTMCOLN3LMNA | |
| SCHEMBL5504038 | 0.77 | ALDH1A1 (0.61) | ALDH1A1L3MBTL1MAPTMCOLN3LMNA | |
| SCHEMBL2875807 | 0.77 | ALDH1A1 (0.61) | ALDH1A1L3MBTL1MAPTMCOLN3LMNA | |
| SCHEMBL4031272 | 0.76 | ALDH1A1 (0.66) | ALDH1A1L3MBTL1MAPTMCOLN3LMNA | |
| SCHEMBL15915230 | 0.76 | MAPT (1.00) | ALDH1A1L3MBTL1MAPTMCOLN3LMNA | |
| SCHEMBL4030282 | 0.76 | ALDH1A1 (0.87) | ALDH1A1L3MBTL1MAPTMCOLN3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066628-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | Sanofi-Aventis (FR) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008014186-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | SANOFI-AVENTIS (FR) | 2008-01-31 | — | — | WO | disclosed |
| EP-1844011-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | Aventis Pharmaceuticals Inc. (US) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006081343-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | AVENTIS PHARMACEUTICALS INC. (US) | 2006-08-03 | — | — | WO | disclosed |