Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 19/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | NPC1 | O15118 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | DRD2 | P14416 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
| ▸ | MTOR | P42345 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20785596 | 1.00 | DRD1 (1.00) | DRD1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL20785604 | 1.00 | DRD1 (1.00) | DRD1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL7451235 | 1.00 | DRD1 (1.00) | DRD1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL7445628 | 1.00 | DRD1 (1.00) | DRD1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL1081313 | 1.00 | DRD1 (1.00) | DRD1KDM4EMAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL30928211 | 0.99 | DRD1 (1.00) | DRD1KDM4EMAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL30914176 | 0.99 | DRD1 (1.00) | DRD1KDM4EMAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL29390394 | 0.99 | DRD1 (1.00) | DRD1KDM4EMAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1878106 | 0.99 | DRD1 (1.00) | DRD1KDM4EMAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5808372 | 0.99 | DRD1 (1.00) | DRD1KDM4EMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150133537-A1 | 3 - (1' - ADAMANTYL) - 1 - AMINOMETHYL - 3, 4 - DIHYDRO - 5, 6 - DIHYDROXY - 1H - 2 - BENZOPYRAN FOR USE IN THE TREATMENT OF A DISEASE ASSOCIATED WITH BETA-AMYLOID INDUCED TOXICITY | THE UNIVERSITY OF MANCHESTER (GB) | 2015-05-14 | — | — | US | claimed |
| EP-2844244-A1 | 3- (1' -ADAMANTYL) - 1 - AMINOMETHYL - 3, 4 - DIHYDRO - 5, 6 - DIHYDROXY - 1H - 2 - BENZOPYRAN FOR USE IN THE TREATMENT OF A DISEASE ASSOCIATED WITH BETA-AMYLOID INDUCED TOXICITY | The University Of Manchester (GB) | 2015-03-11 | — | — | EP | claimed |
| WO-2013156782-A1 | 3- (1' -ADAMANTYL) - 1 - AMINOMETHYL - 3, 4 - DIHYDRO - 5, 6 - DIHYDROXY - 1H - 2 - BENZOPYRAN FOR USE IN THE TREATMENT OF A DISEASE ASSOCIATED WITH BETA-AMYLOID INDUCED TOXICITY | THE UNIVERSITY OF MANCHESTER (GB) | 2013-10-24 | — | — | WO | claimed |
| EP-0474767-B1 | DOPAMINE AGONISTS | ABBOTT LAB (US) | 1996-02-21 | — | — | EP | claimed |
| US-20210038561-A1 | METHODS OF TREATING FIBROTIC PATHOLOGIES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2021-02-11 | — | — | US | disclosed |
| US-20160317474-A1 | Managing Visual Dysfunction or Loss of Vision for Diabetic Subjects | UNIV EMORY (US) | 2016-11-03 | — | — | US | disclosed |
| WO-2015095257-A2 | MANAGING VISUAL DYSFUNCTION OR LOSS OF VISION FOR DIABETIC SUBJECTS | EMORY UNIVERSITY (US) | 2015-06-25 | — | — | WO | disclosed |
| US-20150133537-A1 | 3 - (1' - ADAMANTYL) - 1 - AMINOMETHYL - 3, 4 - DIHYDRO - 5, 6 - DIHYDROXY - 1H - 2 - BENZOPYRAN FOR USE IN THE TREATMENT OF A DISEASE ASSOCIATED WITH BETA-AMYLOID INDUCED TOXICITY | THE UNIVERSITY OF MANCHESTER (GB) | 2015-05-14 | — | — | US | disclosed |
| US-20150133537-A1 | 3 - (1' - ADAMANTYL) - 1 - AMINOMETHYL - 3, 4 - DIHYDRO - 5, 6 - DIHYDROXY - 1H - 2 - BENZOPYRAN FOR USE IN THE TREATMENT OF A DISEASE ASSOCIATED WITH BETA-AMYLOID INDUCED TOXICITY | THE UNIVERSITY OF MANCHESTER (GB) | 2015-05-14 | — | — | US | disclosed |
| US-20150133537-A1 | 3 - (1' - ADAMANTYL) - 1 - AMINOMETHYL - 3, 4 - DIHYDRO - 5, 6 - DIHYDROXY - 1H - 2 - BENZOPYRAN FOR USE IN THE TREATMENT OF A DISEASE ASSOCIATED WITH BETA-AMYLOID INDUCED TOXICITY | THE UNIVERSITY OF MANCHESTER (GB) | 2015-05-14 | — | — | US | disclosed |
| US-20150133537-A1 | 3 - (1' - ADAMANTYL) - 1 - AMINOMETHYL - 3, 4 - DIHYDRO - 5, 6 - DIHYDROXY - 1H - 2 - BENZOPYRAN FOR USE IN THE TREATMENT OF A DISEASE ASSOCIATED WITH BETA-AMYLOID INDUCED TOXICITY | THE UNIVERSITY OF MANCHESTER (GB) | 2015-05-14 | — | — | US | disclosed |
| EP-2844244-A1 | 3- (1' -ADAMANTYL) - 1 - AMINOMETHYL - 3, 4 - DIHYDRO - 5, 6 - DIHYDROXY - 1H - 2 - BENZOPYRAN FOR USE IN THE TREATMENT OF A DISEASE ASSOCIATED WITH BETA-AMYLOID INDUCED TOXICITY | The University Of Manchester (GB) | 2015-03-11 | — | — | EP | disclosed |
| US-20080261950-A1 | Compounds that inhibit cholinesterase | COLUCID PHARMACEUTICALS, INC. (US) | 2008-10-23 | — | — | US | disclosed |
| US-20070275959-A1 | Carbamoyl Esters That Inhibit Cholinesterase And Release Pharmacologically Active Agents | SENTION, INC. | 2007-11-29 | — | — | US | disclosed |
| US-20050096387-A1 | Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents | SENTION, INC. (US) | 2005-05-05 | — | — | US | disclosed |
| WO-1996038435-A1 | DOPAMINE AGONISTS | ABBOTT LABORATORIES (US) | 1996-12-05 | — | — | WO | disclosed |
| EP-0474767-B1 | DOPAMINE AGONISTS | ABBOTT LAB (US) | 1996-02-21 | — | — | EP | disclosed |
| EP-0474767-A4 | DOPAMINE AGONISTS | — | 1992-07-08 | — | — | EP | disclosed |
| EP-0474767-A1 | DOPAMINE AGONISTS. | ABBOTT LAB (US) | 1992-03-18 | — | — | EP | disclosed |
| WO-1990015056-A1 | DOPAMINE AGONISTS | ABBOTT LABORATORIES (US) | 1990-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133537-A1 | 3 - (1' - ADAMANTYL) - 1 - AMINOMETHYL - 3, 4 - DIHYDRO - 5, 6 - DIHYDROXY - 1H - 2 - BENZOPYRAN FOR USE IN THE TREATMENT OF A DISEASE ASSOCIATED WITH BETA-AMYLOID INDUCED TOXICITY | APP, PSEN1, BACE1 | DRD1 540/4885KDM4E 3160/4885MAPT 13/4885 |
| US-20070275959-A1 | Carbamoyl Esters That Inhibit Cholinesterase And Release Pharmacologically Active Agents | ACHE, BCHE, CHAT | DRD1 2439/4885KDM4E 201/4885MAPT 1660/4885 |
| US-20210038561-A1 | METHODS OF TREATING FIBROTIC PATHOLOGIES | MMP1, MMP8, COL2A1 | DRD1 4882/4885KDM4E 3556/4885MAPT 3670/4885 |
| US-20050096387-A1 | Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents | ACHE, BCHE, CHAT | DRD1 2365/4885KDM4E 136/4885MAPT 1588/4885 |
| US-20080261950-A1 | Compounds that inhibit cholinesterase | ACHE, BCHE, CHAT | DRD1 1649/4885KDM4E 1137/4885MAPT 726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.