Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CMA1 | P23946 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27421440 | 0.86 | GPR84 (0.53) | GPR84FFAR1HTR2AHTR2CHTR2B | |
| SCHEMBL27514167 | 0.83 | GPR84 (0.61) | GPR84FFAR1HTR2AHTR2CHTR2B | |
| SCHEMBL1854970 | 0.83 | KMT2A (0.50) | GPR84FFAR1HTR2AHTR2CHTR2B | |
| SCHEMBL368690 | 0.82 | GPR84 (0.59) | GPR84FFAR1HTR2AHTR2CHTR2B | |
| SCHEMBL29885154 | 0.82 | GPR84 (0.59) | GPR84FFAR1HTR2AHTR2CHTR2B | |
| SCHEMBL7563351 | 0.81 | MMP9 (0.56) | GPR84FFAR1KMT2ACYP2D6SLC6A2 | |
| SCHEMBL3996751 | 0.81 | HPGD (0.51) | GPR84FFAR1HTR2AHTR2CHTR2B | |
| SCHEMBL3992783 | 0.81 | GABRP (0.54) | GPR84FFAR1HTR2AHTR2CHTR2B | |
| SCHEMBL29800817 | 0.81 | GPR84 (0.54) | GPR84FFAR1HTR2AHTR2CHTR2B | |
| SCHEMBL1327936 | 0.81 | GPR84 (0.54) | GPR84FFAR1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071888-A1 | PYRROLOTHIAZOLES AS PI3-KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2009-06-11 | — | — | WO | disclosed |