Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 5/20 | 0.36 |
| ▸ | CNR2 | P34972 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 4/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | CFD | P00746 | 1/20 | 0.33 |
| ▸ | BCL6 | P41182 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13769690 | 0.85 | STAT3 (0.38) | PIK3CDCFDBCL6KLKB1 | |
| SCHEMBL4012260 | 0.79 | FPR2 (0.33) | KDM4EALDH1A1KLKB1FPR2 | |
| SCHEMBL4009501 | 0.79 | SCN9A (0.36) | CNR1CNR2KDM4EALDH1A1P2RX7 | |
| SCHEMBL13769756 | 0.75 | VEGFA (0.37) | ALDH1A1EIF2AK3 | |
| SCHEMBL19208112 | 0.75 | CFD (0.37) | KDM4EALDH1A1CFDBCL6P2RX7 | |
| SCHEMBL13769532 | 0.74 | PDE4B (0.41) | KDM4EALDH1A1P2RX7 | |
| SCHEMBL19208282 | 0.73 | HDAC6 (0.39) | KDM4EALDH1A1FPR2 | |
| SCHEMBL4006140 | 0.72 | CNR1 (0.56) | CNR1CNR2KDM4EALDH1A1 | |
| SCHEMBL13769525 | 0.72 | MAPT (0.40) | CNR1CNR2KDM4EALDH1A1P2RX7 | |
| SCHEMBL13769936 | 0.71 | PDE4B (0.42) | KDM4EALDH1A1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |