Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4008336 | 0.94 | HPGD (0.59) | HPGDKMT2ANPC1RAB9APKM | |
| SCHEMBL4008681 | 0.91 | HPGD (0.56) | HPGDTDP1KMT2ANPC1RAB9A | |
| SCHEMBL12231020 | 0.91 | TDP1 (0.55) | HPGDTDP1KMT2ANPC1RAB9A | |
| SCHEMBL5819195 | 0.79 | KMT2A (0.57) | HPGDTDP1KMT2ANPC1RAB9A | |
| SCHEMBL4001873 | 0.78 | RORC (0.48) | HPGDMAPTHTTPOLB | |
| SCHEMBL4001480 | 0.78 | HPGD (0.55) | HPGDKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL9158114 | 0.77 | KMT2A (0.50) | HPGDTDP1KMT2ANPC1RAB9A | |
| SCHEMBL9153545 | 0.77 | ALDH1A1 (0.49) | KMT2ANPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL6569544 | 0.77 | PKM (0.56) | HPGDKMT2ANPC1RAB9APKM | |
| SCHEMBL10660695 | 0.77 | BACE1 (0.52) | HPGDKMT2ANPC1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069286-B1 | INHIBITORS FOR GLYT-1 | HOFFMANN LA ROCHE (CH) | 2012-09-19 | — | — | EP | claimed |
| EP-2069286-A1 | INHIBITORS FOR GLYT-1 | F. Hoffmann-Roche AG (CH) | 2009-06-17 | — | — | EP | claimed |
| US-20080058331-A1 | Inhibitors for GlyT-1 | HOFFMANN-LA ROCHE INC. | 2008-03-06 | — | — | US | claimed |
| WO-2008025694-A1 | INHIBITORS FOR GLYT-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-06 | — | — | WO | claimed |
| EP-2069286-B1 | INHIBITORS FOR GLYT-1 | HOFFMANN LA ROCHE (CH) | 2012-09-19 | — | — | EP | disclosed |
| US-7589089-B2 | Inhibitors for GlyT-1 | HOFFMANN-LA ROCHE INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-7589089-B2 | Inhibitors for GlyT-1 | HOFFMANN-LA ROCHE INC. (US) | 2009-09-15 | — | — | US | disclosed |
| CN-101506148-A | Inhibitors for GLYT-1 | HOFFMANN LA ROCHE (CH) | 2009-08-12 | — | — | CN | disclosed |
| EP-2069286-A1 | INHIBITORS FOR GLYT-1 | F. Hoffmann-Roche AG (CH) | 2009-06-17 | — | — | EP | disclosed |
| EP-2069286-A1 | INHIBITORS FOR GLYT-1 | F. Hoffmann-Roche AG (CH) | 2009-06-17 | — | — | EP | disclosed |
| US-20080058331-A1 | Inhibitors for GlyT-1 | HOFFMANN-LA ROCHE INC. | 2008-03-06 | — | — | US | disclosed |
| US-20080058331-A1 | Inhibitors for GlyT-1 | HOFFMANN-LA ROCHE INC. | 2008-03-06 | — | — | US | disclosed |
| WO-2008025694-A1 | INHIBITORS FOR GLYT-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-06 | — | — | WO | disclosed |
| WO-2008025694-A1 | INHIBITORS FOR GLYT-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058331-A1 | Inhibitors for GlyT-1 | GLRA1, SLC1A2, AGXT | HPGD 3821/4885TDP1 816/4885KMT2A 218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.