Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.47 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | PRKCB | P05771 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | PRKCH | P24723 | 1/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.43 |
| ▸ | RXRA | P19793 | 2/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | CTSE | P14091 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4003440 | 0.82 | L3MBTL1 (0.42) | GPR119BACE1 | |
| SCHEMBL2877376 | 0.79 | PDK2 (0.44) | KDM4EMAPK1 | |
| SCHEMBL1820339 | 0.78 | CALCRL (0.50) | GPR119PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL15848135 | 0.77 | NR1H2 (0.46) | GPR119PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL2604336 | 0.76 | CALCRL (0.58) | MAPK1NAMPT | |
| SCHEMBL7394064 | 0.76 | GPR119 (0.46) | GPR119PRKCGPRKCBPRKCAPRKCH | |
| Hydrochloric Acid SCHEMBL4005503 | 0.76 | PDK4 (0.39) | PRKCGPRKCBPRKCAPRKCHPRKCE | |
| SCHEMBL3276637 | 0.75 | CALCRL (0.46) | GPR119PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL22588214 | 0.73 | OPRM1 (0.57) | GPR119PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL1195957 | 0.73 | NR1H2 (0.51) | GPR119MAPK1NR1H2RXRANR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |