Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4003437 | 0.82 | GPR119 (0.47) | GPR119BACE1 | |
| SCHEMBL2877376 | 0.76 | PDK2 (0.44) | HTTBRD4ALDH1A1 | |
| SCHEMBL13769940 | 0.72 | PDK2 (0.40) | HTTBACE1BRD4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4005503 | 0.71 | PDK4 (0.39) | HTTBACE1BRD4ALDH1A1 | |
| SCHEMBL3941601 | 0.68 | OPRM1 (0.51) | L3MBTL1BRD4KCNH2P2RX4 | |
| SCHEMBL12084233 | 0.67 | CHRM1 (0.53) | L3MBTL1CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL3805407 | 0.67 | KDM4E (0.55) | L3MBTL1CHRM2CHRM5CHRM3HTT | |
| SCHEMBL12934989 | 0.67 | POLB (0.44) | L3MBTL1CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL704010 | 0.67 | RAB9A (0.51) | L3MBTL1CHRM2CHRM1GPR119JAK2 | |
| SCHEMBL13314940 | 0.66 | CHRM1 (0.53) | L3MBTL1CHRM2CHRM1CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |