Hydroxyurea

Hydroxyurea

SCHEMBL4004

NC(=O)NO

nearest known ligand 0.00

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

RRM1RRM2RRM2B

The experimentally established mechanism targets of Hydroxyurea. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydroxyurea SCHEMBL93814 1.00 LMNA (1.00)
Hydroxyurea SCHEMBL5329855 1.00 LMNA (1.00)
Hydroxyurea SCHEMBL28164447 0.95
Hydroxyurea SCHEMBL28783824 0.95
Hydroxyurea SCHEMBL27583606 0.95
Hydroxyurea SCHEMBL23274911 0.95
Hydroxyurea SCHEMBL306433 0.95
Hydroxyurea SCHEMBL15011410 0.95
Hydroxyurea SCHEMBL308240 0.95
Hydroxyurea SCHEMBL28868410 0.95

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 161630 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4748859-A2 CHEMICALLY AND PHOTOCHEMICALLY INITIATED CELL MEMBRANE BLEBBING TO INDUCE CELL VESICLE PRODUCTION, MODIFICATIONS THEREOF, AND USES THEREOF The Regents of the University of California (US) 2026-05-27 EP claimed
EP-3607938-B1 PHARMACEUTICAL COMPOSITION SOVIC BRKICIC LJILJANA (HR) 2026-05-27 EP claimed
EP-4747263-A1 LIPID NANOPARTICLES AND USES THEREOF University of Connecticut (US) 2026-05-27 EP claimed
US-12635917-B2 Remote blood volume monitor DAXOR CORP. (US) 2026-05-26 US claimed
CN-116209439-B Cereblon protein modulators Saint Jude Children's Research Hospital Ltd. (US) 2026-05-26 CN claimed
WO-2026107472-A1 TREATMENT OF SICKLE CELL DISEASE, VASO-OCCLUSIVE CRISES-ASSOCIATED DISEASES, AND/OR THROMBOSIS WITH A HEMOGLOBINASE ENZYME THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2026-05-21 WO claimed
US-20260137685-A1 SOLID PHARMACEUTICAL FORMULATION OF PARP INHIBITORS AND USE THEREOF IMPACT THERAPEUTICS SHANGHAI INC (CN) 2026-05-21 US claimed
US-20260137794-A1 LIGAND-DRUG CONJUGATE AND USE THEREOF SYSTIMMUNE INC (US) 2026-05-21 US claimed
US-20260137686-A1 SOLID PHARMACEUTICAL FORMULATION OF PARP INHIBITORS AND USE THEREOF IMPACT THERAPEUTICS SHANGHAI INC (CN) 2026-05-21 US claimed
WO-2026105121-A1 ANTICANCER FORMULATIONS AND USES THEREOF INTRAGEL THERAPEUTICS LTD. (IL) 2026-05-21 WO claimed
WO-1981000256-A1 (N-PHOSPHONACETYL-L-ASPARTATO)(1,2-DIAMINOCYCLOHEXANE)-PLATINUM(II)OR ALKALI METAL SALT US COMMERCE (US) 1981-02-05 WO claimed
EP-0010964-A1 Ravidomycin, process of preparation and pharmaceutical compositions containing same AYERST, MCKENNA AND HARRISON INC. (CA) 1980-05-14 EP claimed
US-4202890-A 4-Carboxy-phthalato(1,2-diaminocyclohexane)-platinum(II) and alkali metal salts thereof with cyclophosphamide and hydroxyurea in alleviating L1210 murine leukemia THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) 1980-05-13 US claimed
US-4148887-A SUGAR ESTER WITH A METHYL SULFOXIDE THE PROCTER & GAMBLE COMPANY (US) 1979-04-10 US claimed
US-4147767-A CROSSLINKED WITH FORMALDEHYDE OR GLUTARALDEHYDE MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1979-04-03 US claimed
US-4108001-A EPOXY RESIN, THERMAL PROTECTION FOR ELECTRICAL APPARATUS WESTINGHOUSE ELECTRIC CORP. (US) 1978-08-22 US claimed
US-3968249-A HYDROXYUREA E. R. SQUIBB & SONS, INC. (US) 1976-07-06 US claimed
US-3965254-A Compositions for the treatment of calcific tumors THE PROCTER & GAMBLE COMPANY (US) 1976-06-22 US claimed
US-3964912-A Ruthenium containing photographic developers EASTMAN KODAK COMPANY (US) 1976-06-22 US claimed
US-3957990-A INSECTICIDES, ACARICIDES MORTON-NORWICH PRODUCTS, INC. (US) 1976-05-18 US claimed