Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14283752 | 0.85 | PIK3CA (0.39) | PIK3CAPIK3R1PIK3CDPIK3CBMAPKAPK2 | |
| SCHEMBL13441991 | 0.83 | MAPKAPK2 (0.34) | PIK3CAPIK3R1PIK3CDPIK3CBMAPKAPK2 | |
| SCHEMBL3618166 | 0.83 | TBK1 (0.39) | PIK3CAPIK3R1PIK3CDPIK3CBMAPKAPK2 | |
| SCHEMBL14283774 | 0.72 | PIK3CA (0.41) | PIK3CAPIK3R1PIK3CDPIK3CBMAPKAPK2 | |
| SCHEMBL3610717 | 0.70 | PRKAB2 (0.40) | PIK3CAPIK3R1PIK3CDPIK3CBMAPKAPK2 | |
| SCHEMBL13408194 | 0.70 | TBK1 (0.41) | PIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL13442016 | 0.70 | MYLK4 (0.36) | PIK3CAPIK3R1PIK3CDPIK3CBMAPKAPK2 | |
| SCHEMBL14282949 | 0.70 | PIK3CA (0.39) | PIK3CAPIK3R1PIK3CDPIK3CBMAPKAPK2 | |
| SCHEMBL13408206 | 0.68 | TBK1 (0.42) | — | |
| SCHEMBL15344111 | 0.67 | PIK3CA (0.53) | PIK3CAPIK3R1PIK3CDPIK3CBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069333-A1 | PYRROLE DERIVATIVES USEFUL FOR THE TREATMENT OF CYTOKINE-MEDIATED DISEASES | Novartis Ag (CH) | 2009-06-17 | — | — | EP | claimed |
| WO-2008034600-A1 | PYRROLE DERIVATIVES USEFUL FOR THE TREATMENT OF CYTOKINE-MEDIATED DISEASES | NOVARTIS AG (CH) | 2008-03-27 | — | — | WO | claimed |
| EP-2069333-A1 | PYRROLE DERIVATIVES USEFUL FOR THE TREATMENT OF CYTOKINE-MEDIATED DISEASES | Novartis Ag (CH) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008034600-A1 | PYRROLE DERIVATIVES USEFUL FOR THE TREATMENT OF CYTOKINE-MEDIATED DISEASES | NOVARTIS AG (CH) | 2008-03-27 | — | — | WO | disclosed |