Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | PARG | Q86W56 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 2/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7698803 | 0.87 | KMT2A (0.62) | GBA1KMT2AMEN1ALDH1A1CYP2C9 | |
| SCHEMBL4390035 | 0.84 | KMT2A (0.60) | GBA1KMT2AMEN1ALDH1A1CYP2C9 | |
| SCHEMBL4390037 | 0.84 | KMT2A (0.60) | GBA1KMT2AMEN1ALDH1A1CYP2C9 | |
| SCHEMBL4979102 | 0.82 | GBA1 (0.84) | GBA1KMT2AMEN1ALDH1A1CYP2C9 | |
| SCHEMBL7698607 | 0.79 | KMT2A (0.58) | KMT2AMEN1ALDH1A1CYP2C9POLB | |
| SCHEMBL13590685 | 0.78 | ACACB (0.70) | GBA1KMT2AMEN1ALDH1A1CYP2C9 | |
| SCHEMBL2376303 | 0.77 | GBA1 (0.69) | GBA1KMT2AMEN1ALDH1A1CYP2C9 | |
| SCHEMBL4005870 | 0.76 | PARG (0.52) | GBA1KMT2AMEN1ALDH1A1CYP2C9 | |
| SCHEMBL14132588 | 0.74 | ALDH1A1 (0.73) | KMT2AMEN1ALDH1A1POLBLMNA | |
| SCHEMBL3012277 | 0.73 | GBA1 (0.69) | GBA1KMT2AMEN1ALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009082346-A1 | NEW ACETYL COENZYME A CARBOXYLASE (ACC) INHIBITORS AND USES IN TREATMENTS OF OBESITY AND DIABETES MELLITUS - 087 | ASTRAZENECA AB (SE) | 2009-07-02 | — | — | WO | disclosed |