Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 20/20 | 0.45 |
| ▸ | INSR | P06213 | 4/20 | 0.45 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | LATS1 | O95835 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | LYN | P07948 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | INSRR | P14616 | 1/20 | 0.45 |
| ▸ | FECH | P22830 | 1/20 | 0.45 |
| ▸ | MARK3 | P27448 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL528639 | 0.99 | IGF1R (0.44) | IGF1RINSRMAPK3MAPK1RIPK2 | |
| SCHEMBL397577 | 0.90 | IGF1R (0.35) | IGF1RINSRMAPK3MAPK1RIPK2 | |
| SCHEMBL399358 | 0.89 | IGF1R (0.44) | IGF1RINSRMAPK3MAPK1RIPK2 | |
| SCHEMBL400443 | 0.86 | IGF1R (0.34) | IGF1RINSRMAPK3MAPK1RIPK2 | |
| SCHEMBL14938212 | 0.86 | IGF1R (0.33) | IGF1RINSRMAPK3MAPK1RIPK2 | |
| SCHEMBL401574 | 0.85 | IGF1R (0.36) | IGF1RINSRMAPK3MAPK1RIPK2 | |
| SCHEMBL400486 | 0.85 | IGF1R (0.34) | IGF1RINSRMAPK3MAPK1RIPK2 | |
| SCHEMBL399605 | 0.85 | IGF1R (0.46) | IGF1RINSRMAPK3MAPK1RIPK2 | |
| SCHEMBL399135 | 0.85 | IGF1R (0.36) | IGF1RINSRMAPK3MAPK1RIPK2 | |
| SCHEMBL401871 | 0.85 | IGF1R (0.33) | IGF1RINSRMAPK3MAPK1RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017097865-A9 | COMBINATION OF CALORIC RESTRICTION (CR) OR IGF1/INSULIN RECEPTOR INHIBITOR WITH LSD1 INHIBITOR | ISTITUTO EUROPEO DI ONCOLOGIA (IT) | 2017-08-31 | — | — | WO | claimed |
| WO-2017097865-A1 | COMBINATION OF CALORIC RESTRICTION (CR) OR IGF1/INSULIN RECEPTOR INHIBITOR WITH LSD1 INHIBITOR | ISTITUTO EUROPEO DI ONCOLOGIA (IT) | 2017-06-15 | — | — | WO | claimed |
| WO-2016007945-A1 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING CARDIAC HYPERTROPHY | GENESYS RESEARCH INSTITUTE (US) | 2016-01-14 | — | — | WO | claimed |
| US-8575164-B2 | Combination cancer therapy | OSI Pharmaceuticals, LLC (US) | 2013-11-05 | — | — | US | claimed |
| US-20120101084-A1 | Biological Markers Predictive of Anti-Cancer Response to Insulin-Like Growth Factor-1 Receptor Kinase Inhibitors | OSI Pharmaceuticals, LLC | 2012-04-26 | — | — | US | claimed |
| EP-2305682-A1 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI Pharmaceuticals, Inc. (US) | 2011-04-06 | — | — | EP | claimed |
| EP-2131836-A1 | COMBINATION OF IMIDAZO Ý1,5-A¨PYRAZINYL DERIVATIVES WITH AN AGENT THAT INHIBITS SERINE PHOSPHORYLATION OF IRS1 FOR USE IN THE TREATMENT OF CANCER | OSI Pharmaceuticals, Inc. (US) | 2009-12-16 | — | — | EP | claimed |
| EP-1740591-B1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARM INC (US) | 2009-06-17 | — | — | EP | claimed |
| US-7534797-B2 | 6,6-Bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI PHARMACEUTICALS, INC. (US) | 2009-05-19 | — | — | US | claimed |
| US-20080267957-A1 | Combination cancer therapy | OSI PHARMACEUTICALS, INC. | 2008-10-30 | — | — | US | claimed |
| WO-2008106168-A1 | COMBINATION OF IMIDAZO [1,5-A] PYRAZINYL DERIVATIVES WITH AN AGENT THAT INHIBITS SERINE PHOSPHORYLATION OF IRS1 FOR USE IN THE TREATMENT OF CANCER | OSI PHARMACEUTICALS, INC. (US) | 2008-09-04 | — | — | WO | claimed |
| US-20210369714-A1 | Prevention and Treatment of Osteoarthritis by Inhibition of Insulin Growth Factor-1 Signaling | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-12-02 | — | — | US | disclosed |
| WO-2020069208-A1 | PREVENTION AND TREATMENT OF OSTEOARTHRITIS BY INHIBITION OF INSULIN GROWTH FACTOR-1 SIGNALING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-04-02 | — | — | WO | disclosed |
| US-10064939-B2 | Combination therapy using c-Met inhibitor and IGF-1R inhibitor for c-Met inhibitor resistant cancers | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2018-09-04 | — | — | US | disclosed |
| US-9943596-B2 | Combination therapy using dual inhibitor of c-MET and EGFR and IGF-1R inhibitor | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2018-04-17 | — | — | US | disclosed |
| US-20090093488-A1 | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors | OSI PHARMACEUTICALS, INC. | 2009-04-09 | — | — | US | disclosed |
| US-20090092596-A1 | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors | OSI PHARMACEUTICALS, INC. | 2009-04-09 | — | — | US | disclosed |
| US-20080267957-A1 | Combination cancer therapy | OSI PHARMACEUTICALS, INC. | 2008-10-30 | — | — | US | disclosed |
| WO-2008106168-A1 | COMBINATION OF IMIDAZO [1,5-A] PYRAZINYL DERIVATIVES WITH AN AGENT THAT INHIBITS SERINE PHOSPHORYLATION OF IRS1 FOR USE IN THE TREATMENT OF CANCER | OSI PHARMACEUTICALS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |
| US-20060235031-A1 | 6,6-Bicyclic ring substituted heterobicyclic protein kinase inhibitors | ACERTA PHARMA B.V. (NL) | 2006-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101084-A1 | Biological Markers Predictive of Anti-Cancer Response to Insulin-Like Growth Factor-1 Receptor Kinase Inhibitors | IGF1R, IGFBP3, IGFBP1 | IGF1R 1/4885INSR 7/4885MAPK3 65/4885 |
| US-20090092596-A1 | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors | IGF1R, IGFBP3, IGFBP1 | IGF1R 1/4885INSR 8/4885MAPK3 68/4885 |
| US-20080267957-A1 | Combination cancer therapy | IGF1R, IGFBP4, IGFBP1 | IGF1R 1/4885INSR 10/4885MAPK3 898/4885 |
| US-10064939-B2 | Combination therapy using c-Met inhibitor and IGF-1R inhibitor for c-Met inhibitor resistant cancers | MET, IGF1R, IGFBP1 | IGF1R 2/4885INSR 22/4885MAPK3 1650/4885 |
| US-20090093488-A1 | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors | IGF1R, IGFBP3, IGFBP1 | IGF1R 1/4885INSR 8/4885MAPK3 68/4885 |
| US-20060235031-A1 | 6,6-Bicyclic ring substituted heterobicyclic protein kinase inhibitors | IGF1R, MAP2K7, BRCA1 | IGF1R 1/4885INSR 27/4885MAPK3 61/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.