SCHEMBL4007630

SCHEMBL4007630

CCCCCCC(CC)Cc1ccccc1OP(Oc1ccccc1CC(CC)CCCCCC)Oc1ccccc1CC(CC)CCCCCC

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRSS1 P07477 1/20 0.45
PRSS2 P07478 1/20 0.45
PRSS3 P35030 1/20 0.45
THRA P10827 1/20 0.38
THRB P10828 1/20 0.38
ALDH1A1 P00352 3/20 0.38
CYP3A4 P08684 2/20 0.38
CA2 P00918 1/20 0.38
CSNK1E P49674 1/20 0.35
TSHR P16473 1/20 0.35
LMNA P02545 3/20 0.35
LIPG Q9Y5X9 1/20 0.34
ALOX5 P09917 1/20 0.34
PTGS2 P35354 1/20 0.34
KDM4E B2RXH2 1/20 0.34
PPARG P37231 2/20 0.34
PPARA Q07869 1/20 0.33
MEN1 O00255 1/20 0.33
NR1I2 O75469 1/20 0.33
CHRM2 P08172 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4006592 0.94 ALDH1A1 (0.42) PRSS1PRSS2PRSS3THRATHRB
SCHEMBL9474257 0.92 THRA (0.46) PRSS1PRSS2PRSS3THRATHRB
SCHEMBL29813681 0.84 L3MBTL1 (0.34) ALDH1A1CYP3A4CHRM2MAPTSLC6A3
SCHEMBL10470156 0.84 ALDH1A1 (0.43) PRSS1PRSS2PRSS3THRATHRB
SCHEMBL11395011 0.83 ALDH1A1 (0.36) PRSS1PRSS2PRSS3ALDH1A1CYP3A4
SCHEMBL7784137 0.81 ALDH1A1 (0.44) PRSS1PRSS2PRSS3ALDH1A1CYP3A4
SCHEMBL29385746 0.77 ALDH1A1 (0.47) PRSS1PRSS2PRSS3ALDH1A1CYP3A4
SCHEMBL153633 0.77 ALDH1A1 (0.47) PRSS1PRSS2PRSS3ALDH1A1CYP3A4
SCHEMBL28622222 0.77 PRSS1 (0.48) PRSS1PRSS2PRSS3ALDH1A1CYP3A4
SCHEMBL9070058 0.77 THRA (0.45) PRSS1PRSS2PRSS3THRATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1890998-B1 PROCESS FOR THE PREPARATION OF POLYISOCYANATES OF THE DIPHENYLMETHANE SERIES HUNTSMAN INT LLC (US) 2014-02-26 EP disclosed
WO-2009077795-A1 PROCESS FOR THE PREPARATION OF POLYISOCYANATES OF THE DIPHENYLMETHANE SERIES BORSODCHEM ZRT (HU) 2009-06-25 WO disclosed
EP-1890998-A2 PROCESS FOR THE PREPARATION OF POLYISOCYANATES OF THE DIPHENYLMETHANE SERIES HUNTSMAN INTERNATIONAL LLC (US) 2008-02-27 EP disclosed
WO-2006130405-A2 PROCESS FOR THE PREPARATION OF POLYISOCYANATES OF THE DIPHENYLMETHANE SERIES HUNTSMAN INTERNATIONAL LLC (US) 2006-12-07 WO disclosed
US-6576788-B1 METHOD FOR PRODUCING MIXTURES CONSISTING OF DIPHENYLMETHANE DIISOCYANATES AND POLYPHENYLENE-POLYMETHYLENE-POLYISOCYANATES CONTAINING A REDUCED AMOUNT OF CHLORINATED SECONDARY PRODUCTS AND WITH A REDUCED IODINE COLOR INDEX BASF AKTIENGESELLSCHAFT (DE) 2003-06-10 US disclosed
US-5208368-A Reaction of diamine with phosgene in a solvent BASF AKTIENGESELLSCHAFT (DE) 1993-05-04 US disclosed