Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.56 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.56 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8036853 | 0.88 | SIRT2 (0.54) | SIRT2SIRT1SIRT3TP53MDM2 | |
| SCHEMBL8032162 | 0.85 | SIRT2 (0.52) | SIRT2SIRT1SIRT3TP53MDM2 | |
| SCHEMBL8022429 | 0.85 | SIRT2 (0.52) | SIRT2SIRT1SIRT3TP53MDM2 | |
| SCHEMBL22712554 | 0.85 | USP2 (0.48) | SIRT2TP53LMNAUSP2TSHR | |
| SCHEMBL8345138 | 0.83 | SIRT2 (0.59) | SIRT2SIRT1SIRT3TP53MDM2 | |
| SCHEMBL22712539 | 0.82 | HSD17B10 (0.46) | SIRT2SIRT1SIRT3TP53LMNA | |
| SCHEMBL4007745 | 0.80 | SIRT2 (0.48) | SIRT2SIRT1SIRT3TP53LMNA | |
| SCHEMBL22712550 | 0.79 | GAA (0.45) | LMNAUSP2TSHRMAPK1HSD17B10 | |
| SCHEMBL8042850 | 0.77 | ALDH1A1 (0.47) | SIRT2SIRT1SIRT3USP2TSHR | |
| SCHEMBL4949585 | 0.77 | KDM4E (0.63) | SIRT2SIRT1SIRT3TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080248-A1 | SUBSTITUTED 2-PHENYLPYRIMIDINE-5-CARBOXYLIC ACIDS AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009080242-A1 | SUBSTITUTED 4-AMINOPYRIMIDINE-5-CARBOXYLIC ACID AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-07-02 | — | — | WO | disclosed |