Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 11/20 | 0.67 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4014998 | 0.85 | FAAH (0.70) | FAAHEPHX2ALPLALDH1A1KDM4E | |
| SCHEMBL4012470 | 0.84 | FAAH (0.78) | FAAHEPHX2ALPLALDH1A1LMNA | |
| SCHEMBL3931338 | 0.84 | FAAH (0.79) | FAAHEPHX2ALPLALDH1A1TNF | |
| SCHEMBL3936952 | 0.84 | FAAH (0.72) | FAAHEPHX2ALPLALDH1A1TNF | |
| SCHEMBL3936894 | 0.83 | FAAH (0.79) | FAAHEPHX2ALPLALDH1A1TNF | |
| SCHEMBL4011830 | 0.82 | FAAH (0.65) | FAAHEPHX2ALPLALDH1A1TNF | |
| SCHEMBL4019611 | 0.82 | FAAH (0.65) | FAAHEPHX2ALPLALDH1A1TNF | |
| SCHEMBL3932569 | 0.82 | FAAH (0.79) | FAAHEPHX2ALDH1A1TNFLMNA | |
| SCHEMBL4016142 | 0.82 | FAAH (0.67) | FAAHEPHX2ALPLALDH1A1LMNA | |
| SCHEMBL3929062 | 0.82 | FAAH (0.75) | FAAHALPLLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009011904-A1 | COMPOUNDS USEFUL AS FAAH MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2009-01-22 | — | — | WO | disclosed |
| WO-2009011904-A1 | COMPOUNDS USEFUL AS FAAH MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2009-01-22 | — | — | WO | disclosed |