Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 10/20 | 0.65 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4011830 | 0.87 | FAAH (0.65) | FAAHEPHX2BRAFEIF2AK3ALPL | |
| SCHEMBL4016142 | 0.85 | FAAH (0.67) | FAAHEPHX2BRAFEIF2AK3ALPL | |
| SCHEMBL4014998 | 0.84 | FAAH (0.70) | FAAHEPHX2ALPLALDH1A1KDM4E | |
| SCHEMBL3936641 | 0.83 | FAAH (0.71) | FAAHALDH1A1TNFLMNAMAPK1 | |
| SCHEMBL4007889 | 0.82 | FAAH (0.67) | FAAHEPHX2ALPLALDH1A1TNF | |
| SCHEMBL3931250 | 0.82 | FAAH (0.74) | FAAHMEN1GAACASP1KMT2A | |
| SCHEMBL4012470 | 0.81 | FAAH (0.78) | FAAHEPHX2ALPLALDH1A1LMNA | |
| SCHEMBL3940445 | 0.81 | FAAH (0.84) | FAAHMEN1GAAKMT2AEPHX2 | |
| SCHEMBL3942809 | 0.80 | FAAH (0.74) | FAAHEPHX2ALPLALDH1A1TNF | |
| SCHEMBL3943336 | 0.80 | FAAH (0.77) | FAAHEPHX2ALPLALDH1A1TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009011904-A1 | COMPOUNDS USEFUL AS FAAH MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2009-01-22 | — | — | WO | disclosed |