Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | VCP | P55072 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13770142 | 0.85 | JAK2 (0.48) | JAK2JAK3SRCKDM4EALDH1A1 | |
| SCHEMBL4006132 | 0.79 | P2RX7 (0.43) | PTGS2P2RX7FGFR1FGFR4SRC | |
| SCHEMBL4005527 | 0.79 | MAPT (0.44) | — | |
| SCHEMBL23885536 | 0.78 | ADK (0.43) | SRCALDH1A1TEK | |
| SCHEMBL4005517 | 0.78 | ADK (0.42) | P2RX7FGFR1FGFR4SRC | |
| SCHEMBL4008751 | 0.76 | CSNK2A2 (0.35) | P2RX7ALOX15SRCKDM4EALDH1A1 | |
| SCHEMBL4007142 | 0.75 | FLT4 (0.43) | PTGS2HSD17B10SRCKDM4EALDH1A1 | |
| SCHEMBL4014223 | 0.73 | HTT (0.42) | ALOX15KDM4EALDH1A1 | |
| SCHEMBL4008412 | 0.68 | CSNK2A2 (0.38) | PTGS2KDM4EALDH1A1 | |
| SCHEMBL23885118 | 0.67 | SRC (0.55) | SRCTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |