Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13770127 | 0.83 | HTR2C (0.42) | MEN1KMT2ASMN1; SMN2LMNAMAPT | |
| SCHEMBL4006053 | 0.77 | LMNA (0.47) | HTTMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL23885536 | 0.77 | ADK (0.43) | ALDH1A1 | |
| SCHEMBL4005517 | 0.77 | ADK (0.42) | MEN1KMT2A | |
| SCHEMBL4008751 | 0.75 | CSNK2A2 (0.35) | KMT2ALMNAMAPTALOX15ALDH1A1 | |
| SCHEMBL4007142 | 0.74 | FLT4 (0.43) | MAPTALDH1A1HPGDPOLBKDM4E | |
| SCHEMBL4007971 | 0.73 | PTGS2 (0.48) | ALOX15ALDH1A1KDM4E | |
| SCHEMBL4005527 | 0.70 | MAPT (0.44) | MAPT | |
| SCHEMBL13770156 | 0.69 | MAPT (0.37) | MEN1KMT2ASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL3533481 | 0.68 | SMN1; SMN2 (0.46) | HTTMEN1KMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |