Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CCR4 | P51679 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4008751 | 0.80 | CSNK2A2 (0.35) | KDRCSNK2A1CSNK2A2ALDH1A1ADORA2B | |
| SCHEMBL23885536 | 0.79 | ADK (0.43) | KDRALDH1A1ADORA2BSRC | |
| SCHEMBL4005517 | 0.79 | ADK (0.42) | CSNK2A1CSNK2A2HDAC6SRCEPHX2 | |
| SCHEMBL4008754 | 0.76 | FLT4 (0.44) | FLT4KDRCCR4HPGDALDH1A1 | |
| SCHEMBL4007971 | 0.75 | PTGS2 (0.48) | HSD17B10PTGS2ALDH1A1SRCKDM4E | |
| SCHEMBL4014223 | 0.74 | HTT (0.42) | HPGDALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL8769186 | 0.73 | FLT4 (0.72) | FLT4KDRCSNK2A1CSNK2A2PTGS2 | |
| SCHEMBL2236505 | 0.73 | DGAT1 (0.38) | — | |
| SCHEMBL4005527 | 0.72 | MAPT (0.44) | CSNK2A1MAPT | |
| SCHEMBL4008412 | 0.69 | CSNK2A2 (0.38) | CSNK2A1CSNK2A2PTGS2HDAC6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |