Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 6/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.40 |
| ▸ | P2RY1 | P47900 | 5/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4007180 | 0.88 | TRPA1 (0.57) | PDE10ATRPA1HTR1ASLC6A2SLC6A4 | |
| SCHEMBL4012114 | 0.85 | TRPA1 (0.49) | PDE10ATRPA1HTR1ASLC6A2SLC6A4 | |
| SCHEMBL4011485 | 0.80 | P2RY1 (0.49) | PDE10ATRPA1HTR1ASLC6A2SLC6A4 | |
| SCHEMBL4008138 | 0.79 | HTR1A (0.54) | PDE10ATRPA1HTR1ASLC6A2SLC6A4 | |
| SCHEMBL4006790 | 0.77 | HTR1A (0.56) | TRPA1HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL31395515 | 0.77 | PDE10A (0.53) | PDE10ATRPA1CYP2C9CYP2C19 | |
| SCHEMBL31395497 | 0.76 | CARM1 (0.47) | PDE10ATRPA1CARM1PRMT6 | |
| SCHEMBL25216729 | 0.76 | PDE10A (0.47) | PDE10AMAPTP2RY1CYP2C19 | |
| SCHEMBL4009120 | 0.76 | HTR1A (0.47) | PDE10AHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL31395528 | 0.76 | PDE10A (0.46) | PDE10AP2RY1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009081259-A1 | PHENOXY-PYRIDYL DERIVATIVES | PFIZER INC. (US) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009081259-A1 | PHENOXY-PYRIDYL DERIVATIVES | PFIZER INC. (US) | 2009-07-02 | — | — | WO | disclosed |