SCHEMBL400889

SCHEMBL400889

COC(=O)c1cccc(Cl)n1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.55
SMN1; SMN2 Q16637 3/20 0.55
NPC1 O15118 2/20 0.55
RAB9A P51151 2/20 0.55
TP53 P04637 1/20 0.55
CYP3A4 P08684 1/20 0.55
CYP2C9 P11712 1/20 0.55
CYP2C19 P33261 1/20 0.55
MAPT P10636 4/20 0.54
GAA P10253 2/20 0.51
RECQL P46063 1/20 0.51
L3MBTL1 Q9Y468 2/20 0.51
ALDH1A1 P00352 5/20 0.50
MRGPRX4 Q96LA9 1/20 0.48
KDM4E B2RXH2 2/20 0.46
GRM5 P41594 1/20 0.46
HPGD P15428 1/20 0.46
TSHR P16473 1/20 0.46
HSD17B10 Q99714 1/20 0.46
IRAK4 Q9NWZ3 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31264274 1.00 CYP1A2 (0.55) CYP1A2SMN1; SMN2NPC1RAB9ATP53
SCHEMBL69653 0.86 MAPT (0.64) CYP1A2SMN1; SMN2NPC1RAB9ATP53
SCHEMBL8571638 0.82 CYP1A2 (0.44) CYP1A2SMN1; SMN2NPC1RAB9ATP53
SCHEMBL13018321 0.82 CYP1A2 (0.44) CYP1A2SMN1; SMN2NPC1RAB9ATP53
SCHEMBL9426972 0.81 CYP1A2 (0.59) CYP1A2SMN1; SMN2NPC1RAB9ATP53
SCHEMBL28179233 0.81 TSHR (0.44) CYP1A2SMN1; SMN2NPC1RAB9ATP53
SCHEMBL30077004 0.80 CYP1A2 (0.43) CYP1A2SMN1; SMN2NPC1RAB9ATP53
SCHEMBL32668996 0.80 ALDH1A1 (0.61) CYP1A2SMN1; SMN2NPC1RAB9ATP53
SCHEMBL31337797 0.80 CYP1A2 (0.77) CYP1A2SMN1; SMN2NPC1RAB9AMAPT
SCHEMBL12468872 0.80 CYP1A2 (0.43) CYP1A2SMN1; SMN2NPC1RAB9ATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 395 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250257050-A1 PROCESS FOR THE PREPARATION OF VORASIDENIB SERVIER PHARMACEUTICALS LLC 2025-08-14 US claimed
CN-119592966-A Method for synthesizing ester compounds by high-selectivity dechlorination electro-catalysis 浙江工业大学 2025-03-11 CN claimed
CN-111151248-A Method for catalyzing heterocyclic halogen-containing organic matter hydrogenation dehalogenation by using supported metal oxide 浙江大学 2020-05-15 CN claimed
EP-3704101-B1 COCRYSTALS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF TREATMENT INVOLVING SAME SERVIER LAB (FR) 2026-05-06 EP disclosed
US-20260055108-A1 TRIAZINE COMPOUNDS AND USES THEREOF HUTCHMED LTD (CN) 2026-02-26 US disclosed
US-12528815-B2 5-amino-8-(4-pyridyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one compounds for use against cancer NXERA PHARMA UK LIMITED (GB) 2026-01-20 US disclosed
EP-4676918-A1 COMPOUNDS AND THEIR USES AS GPR183 INHIBITORS Nanjing Immunophage Biomedical Co., Ltd. (CN) 2026-01-14 EP disclosed
EP-4647076-A2 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE Les Laboratoires Servier (FR) 2025-11-12 EP disclosed
US-12433895-B2 Therapeutically active compounds and their methods of use SERVIER PHARMACEUTICALS LLC (US) 2025-10-07 US disclosed
US-20250304603-A1 OXABOROLE ESTERS AND USES THEREOF ANACOR PHARMACEUTICALS INC (US) 2025-10-02 US disclosed
EP-4620533-A2 ANTAGONIST COMPOUNDS Adorx therapeutics Limited (GB) 2025-09-24 EP disclosed
EP-0488474-A1 Herbicidal carboxamide derivatives SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1992-06-03 EP disclosed
WO-1991015476-A1 SUBSTITUTED CYCLOHEXANEDIONES AND THEIR HERBICIDAL USES DOWELANCO (US) 1991-10-17 WO disclosed
EP-0450712-A2 Substituted cyclohexanediones and their herbicidal uses DOWELANCO (US) 1991-10-09 EP disclosed
EP-0447004-A2 Herbicidal carboxamide derivatives SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1991-09-18 EP disclosed
US-5013352-A Grassy weeds in presence of crops DOWELANCO (US) 1991-05-07 US disclosed
US-5010201-A Process for the preparation of substituted 2-chloropyridines BAYER AKTIENGESELLSCHAFT (DE) 1991-04-23 US disclosed
US-4499275-A PESTICIDES; INSECTICIDES NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1985-02-12 US disclosed
US-4393213-A Process for producing 6-phenoxypicolinic aldehydes NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1983-07-12 US disclosed
US-4251662-A INSECTICIDES, MITICIDES NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1981-02-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12433895-B2 Therapeutically active compounds and their methods of use MCL1, TP53, BRDT CYP1A2 4636/4885SMN1; SMN2 568/4885NPC1 513/4885
US-20250304603-A1 OXABOROLE ESTERS AND USES THEREOF OXA1L, HSD17B12, OXER1 CYP1A2 247/4885SMN1; SMN2 442/4885NPC1 1483/4885
US-20250257050-A1 PROCESS FOR THE PREPARATION OF VORASIDENIB SAMHD1, DPYD, MVD CYP1A2 492/4885SMN1; SMN2 1870/4885NPC1 1258/4885
US-20260055108-A1 TRIAZINE COMPOUNDS AND USES THEREOF CBR1, CNR1, CBR3 CYP1A2 134/4885SMN1; SMN2 3344/4885NPC1 130/4885
US-12528815-B2 5-amino-8-(4-pyridyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one compounds for use against cancer ADORA1, ADORA3, OPRL1 CYP1A2 1308/4885SMN1; SMN2 1824/4885NPC1 488/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.