Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 14/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.45 |
| ▸ | CLK2 | P49760 | 3/20 | 0.44 |
| ▸ | CLK3 | P49761 | 3/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CCND3 | P30281 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4009386 | 0.82 | ITK (0.56) | ITKFGFR1CLK2CLK3DYRK1A | |
| SCHEMBL4011766 | 0.80 | ITK (0.54) | ITKFGFR1CLK2CLK3DYRK1A | |
| SCHEMBL4010514 | 0.74 | ITK (0.56) | ITKFGFR1CLK2CLK3DYRK1A | |
| SCHEMBL4008243 | 0.73 | ITK (0.48) | ITKFGFR1CLK2CLK3DYRK1A | |
| SCHEMBL4008935 | 0.73 | FGFR1 (0.56) | ITKFGFR1CHEK1CDK4CCNA2 | |
| SCHEMBL1459731 | 0.73 | ITK (0.53) | ITKFGFR1CLK2CLK3DYRK1A | |
| SCHEMBL18487449 | 0.72 | ITK (0.68) | ITKFGFR1CLK2CLK3DYRK1A | |
| SCHEMBL4008937 | 0.71 | TRPA1 (0.48) | FGFR1CLK2CLK3DYRK1ACDK2 | |
| SCHEMBL4008930 | 0.70 | SCN9A (0.36) | FGFR1KDR | |
| SCHEMBL3927404 | 0.70 | ITK (0.73) | ITKFGFR1CHEK1CDK4CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7473701-B2 | Substituted indazoles, compositions containing them, method of production and use | AVENTIS PHARMA S.A. (FR) | 2009-01-06 | — | — | US | claimed |